Term
|
Definition
| defective apo B or no syn of normal protein in enterocytes...cant form chylomicrons...buildup of fat w/i enterocytes |
|
|
Term
|
Definition
| serve as coenzyme for homocysteine:methionine methyltransferase that converts homocysteine to methionine |
|
|
Term
| Cobalamin (b12) binds to 1st..then?? |
|
Definition
| haptocorrin (R factor) in stomach..then IF in duodenum |
|
|
Term
|
Definition
| b12 absorption/ bile acid abs |
|
|
Term
| fat soluble vitamins (where stored) |
|
Definition
|
|
Term
| Calcium- 2 methods of abs |
|
Definition
passive -small int-(Vit D independent)
Active-DUO-(Vit D stims all three steps) |
|
|
Term
|
Definition
passive-small int-
active-ILEUM |
|
|
Term
|
Definition
DUO-receptor mediated endocytosis- transferrin--mobilferrin-(IREG1)-ferritin/
Divalent cation transp. (DCT1) |
|
|
Term
| products of gastric lipase |
|
Definition
diglyceride and fatty acid
secr by CHIEF cells |
|
|
Term
| prods of pancreatic lipase |
|
Definition
2 fatty acids and 2-monoglyceride
secr by pancreatic ACINAR cells (requires cofactor colipase) |
|
|
Term
| pancreatic phospholipase A2 |
|
Definition
can yield lysophospholipds--reqs bile salt
-optimum 7.5 |
|
|
Term
| bile acids or salts- lipophil/lipophobic? |
|
Definition
| amphi--form micelles--mixed micelles |
|
|
Term
| 3 ways lipolytic products enter enterocytes |
|
Definition
| diffusion, collision, active transporters |
|
|
Term
| Cholesterol abs inhibitor |
|
Definition
| ezetimibe (inhibits NPC1L1) |
|
|
Term
| absorbed lipid products bind to what in cytosol of enterocyte |
|
Definition
| faaty acid binding protein |
|
|
Term
| B48 syn where? what has B48? |
|
Definition
| syn in intetine (B100 in liver) chylomicrons have b48 |
|
|
Term
|
Definition
| transport exogenous TGs & chol from intestine to tissues (adipose, muscle, liver) |
|
|
Term
| Liver big regulator of blood glc--normal liver...insulin inhibits? |
|
Definition
| gluconeogenesis..type 2 diabtese=insulin cant suppres gluconeo |
|
|
Term
| urea exits hepatocyte through |
|
Definition
|
|
Term
|
Definition
| transp. TGs & chol from LIVER to NONHEPATIC tissues |
|
|
Term
|
Definition
| reverse chol tport (tissue to LIVER) |
|
|
Term
|
Definition
| major chol carrier of bloodstream |
|
|
Term
Familial Hypercholest.
Heterzy levels
Homo levels |
|
Definition
hete-350-550
homo-650-1000 |
|
|
Term
| 3 ways liver imports cholest |
|
Definition
take up remn chylo
syn de novo
from LDL receptor mediated endocytosis |
|
|
Term
de noveo chol syn liver details
rate lim step?
starting substrate? |
|
Definition
HMG coA reductase
syns chol from Acetyl coA |
|
|
Term
Hepatic bile comp to plasma
Gallbladder bil |
|
Definition
hep-isotonic
gall-acidic (6.5) |
|
|
Term
|
Definition
| principal route for cholesterol excretion. only way the body can get rid of excess cholesterol. |
|
|
Term
bile acids syn exclusively in?
precursor?
1st step catalyzed by? |
|
Definition
|
|
Term
| 95% of bile acids (1 &2) are CONJUGATED with what & what? |
|
Definition
|
|
Term
activates bile acid syn
suppresses synthesis |
|
Definition
Liver X receptor (LXRa)
Farnesoid X receptor (FXR) |
|
|
Term
|
Definition
proton pump inhib
blocks Histamine rec (causes big decr acid bc lose aditive effect |
|
|
Term
cystinuria--impaired abs of?
HArtnup- def abs of? |
|
Definition
HCOAL His, Cys, Orni, ARG, LYS
Hartnup- Phen |
|
|
