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| reproductive, renal, respiratory, digestive systems have outs, circulatory, nervous, endocrine, muskulaskeletal, and immune don't |
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| ligand, ligand + recepor, enzymes, 2nd messengers, enzymes, response! |
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| agonist: mimics a ligand (insulin). antagonist: inhibits the action of a ligand (beta blockers) |
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| types of ligand receptors |
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Definition
| ligand-gated ion channel, g-protein receptors (releases protein subunits), receptor tyrosine kinases (rtk, dimerize), receptors linked to enzymes |
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| cell-cell, autocrine (like t-cells, self stimulating), paracrine (chemical synapses, eg), endocrine (eg hormones) |
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| protein horomone/steroid hormone diffs |
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Definition
protein: hydrophilic, binds to surface receptors steroids: hydrophobic, bind to intracellular receptors |
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| how the synapse balance works |
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Definition
| [K] larger in than out, [Na] larger out than in, opening [K] channels makes a gradient force, but the voltage force plays too! |
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| dendrites, axon, soma, axon terminals, myelin sheaths, nodes of ranvier |
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| draw the action potential mechanism voltage diagram |
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| study of host protection from foreign macromolecules or invading response to them |
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| four classes of pathogens? |
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| bacteria, viruses, fungi, and parasites |
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| innate (for extracellular) or adaptive (humoral or cell mediated, for vesicular or cytosolic antigens) |
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| how an infected cell is destroyed |
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Definition
MHC-I shows protein part that is recognized by T-cytotoxic cell, that activates other T-c cells to kill 'em. OR phagocytosis and presentation by mhc-II and recognized by Thelper which activate other Thelper to get B cells producing antibodies or gets macrophages |
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| a preparation of all or part of an infectious agent that primes the immune system to recognize it, without causing it |
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| jenner made vaccine from cowpox lesions in dairymaids (probs - arm-to-arm method, and length of protection) |
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| biotech of smallpox vaccine |
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Definition
| naturally occuring, attenuated vaccine. 1940s showed large scale production of freeze dried vaccine |
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| secondary much quicker and stronger than primary |
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| prepares killed vaccine for polio (later someone develops oral) |
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Definition
natural, attenuated live vaccine (smallpox) killed virus (salk polio) lab attenuated virus (sabin polio) purificiation of subunit (hep. b) rcombinant dna to produce subunit (now hep b) dna vaccine (investigational) |
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