Term
| Which Womens Health Initiative Study was stopped in 2002? |
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Definition
| The Estrogen plus Progestin trial...why? bc of inc heart attack risk |
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Term
| An example of a SERM aka designer estrogen is? |
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Definition
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Term
| During infertility treatment, which of the following is MOST LIKELY to induce ovulation? |
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Definition
| Clomiphene citrate or Gonadotropin admin but that is $$$$ |
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Term
| What is the MOA os Clomiphene citrate? |
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Definition
| Partial E receptor agonist. Makes the pituitary think that the ovaries are not responding which results in increased production and release of FSH-->ovaries work harder! |
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Term
| Indications for using Pitocin? |
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Definition
| fetal distress, membrane rupture w/ risk of infxn, chorioamnionitis, premature placental detachement (abruption) |
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Term
| What are the Tocolytic agents? |
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Definition
-Mg Sulfate
-B2- Adrenergic agonists
-CCB
-PG synthetase inhibitors |
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Term
| Biggest benefit of oral contraceptives? |
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Definition
| Reduced incidence of ovarian cancer |
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Term
| Pt is in early labor, <4 cm dilate, <80% effaced at 21 weeks. what do you give her? |
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Definition
| Ritodrine, terbutaline or Fenoterol. If she can't have B2agonist, give Mg SUlfate! |
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Term
| Physiological Effects of Beta 2 agonists? |
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Definition
| Relaxation of smooth muscle: vascular bronchial, GI, genitourinary, skeletal and liver |
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Term
| What is the Estrogen + Progestin Contraceptive? |
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Definition
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Term
| A 17 yr old male is about to undergo trans-urethral resecton due to prostatic hyperplasia- which of the following statements is correct? |
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Definition
| -An inhaled anesthetic with a high MAC value is best |
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Term
| Which inhaled anesthetic is most likely to be eliminated by enzymatic degradation of the liver? |
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Definition
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Term
| a 32 y/o F anesthetized with sevoflurane for gallbladder removal would experience what? |
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Definition
| Increased cerebral BF and Increased ICP |
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Term
| Blockade of small diameter sensory neurons by admin of a local anesthetic prior to blockage of larger diameter motor neurons would be observed in |
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Definition
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Term
| best drug to use for a surgical procedue repairing the arm in a pt with a head injury? Or the best drug to use for a surgical splenectomy after a head injury?MOA |
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Definition
| IV anesthesia- Thiopental--short acting |
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Term
| IV anesthetic that is reported to make pts 'feel better' after use |
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Definition
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Term
| Process of breast feeding elevates WHAT? which has an anti-gonadotropic effect causing a lac of ovulation? |
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Definition
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Term
| 28 yr old F in active labor for several hours, membranes ruptured by progress suddenly halts. Which drug will bring her back into active labor? |
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Definition
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Term
| What are the tocolytics? My B Can't Push! |
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Definition
| Mg Sulfate, B agonist, CCB, PG synthetase inhib-indomethacin |
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Term
| What effect does morphine have on halothane? |
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Definition
| Slows the onset of anesthesia |
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Term
| MOA of local anesthetics (-Caine) |
|
Definition
| blocks v gated Na channels |
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Term
|
Definition
| produce uterine contractions |
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Term
| Agent that has a high affinity for GnRH receptors and immediately suppreses gonadotropin secretion? |
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Definition
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Term
| CI for oral contraceptive? |
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Definition
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Term
| To tx infertility secondary to a prolactinoma |
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Definition
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Term
| A contraceptive which promotes luteolysis and is also an abortificant? |
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Definition
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Term
| What tacolytics have AE of hypotension and reflex tachycardia? |
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Definition
| B2 agonists (Three ripe farts)- ritodrine, terbutaline, fenoterol |
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Term
| Drug that used at a high dose with PGE1 sensitezes oxytocin receptors and produces strong uterine contractions |
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Definition
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Term
| Drug used to stimulate ovulations that has an AE of VISUAL SYMPTOMS |
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Definition
| Clomiphene (clouds your vision) |
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Term
| what are the ovarian hormones? |
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Definition
| Progesterone, Estogen (Estradiol>estrone) |
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Term
|
Definition
| Mestranol(it's an Estrogen and an answer on an old exam...but CLONIDINE is prob better) |
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Term
| MOA of Estrogen therapy in a post-menopausal pt? |
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Definition
| works at level of transcription.. binds at the receptor, kicks out HSP90-->dimerization-->recruit coactivators |
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Term
| Oxytocin stimulates PG production by |
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Definition
| Endometrial/decidual cells |
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Term
| if a pregnant women is <4 cm dilated and less than 80% effaced, what drug can you NOT give? |
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Definition
|
|
Term
| absolute contraindication for admin of oxytocin? |
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Definition
| abnormal fetal position-- ie transverse lie |
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Term
|
Definition
| inhibits FSH and LH via negative feedback |
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|
Term
| do NOT give this contraceptive to a female with a hx of thrombophlebitis |
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Definition
|
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Term
|
Definition
| estrogen receptor agonist that increases LH and FSH to promote ovulation |
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Term
| hCG sitmulates production of gonadal steroid hormones by stimulating: |
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Definition
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Term
| MOA of opiods for chronic severe pain |
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Definition
| neuronal hyperpolarization due to decreased conductance or Ca/K |
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Term
| An unconscious male btwn 25-30 years old is brought to the ED. He is hypotensive, has shallow breathing and is hypercapnic and hypoxic. His pupils are constricted. Pt may be suffering from: |
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Definition
| an overdose of morphine and should be treated with Naloxone |
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Term
| 59 year old F with hx of DM dev gangrene and needs her foot amputated. To treat post op pain she is given 2 wks of morphine. In addtion to this she should be given: |
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Definition
| daily admin of a laxitive (opiods make you constipated!) |
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Term
| The potency of all other opiod drugs is described in comparison to |
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Definition
|
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Term
| weakly binds Mu receptors and enhances 5HT neurotransmission |
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Definition
| tramadol (atypical opiod) |
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Term
| mixed opiod agonist/antagonist that is likely to cause hallucinations |
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Definition
|
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Term
| dose limiting effect of opiods is effect on |
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Definition
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Term
| opiod MC rx'd for pain and cough suppression |
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Definition
| codeine (chronic admin predisposes to infxn) |
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Term
| two SE of chronic opiod use that you never dev tolerance to |
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Definition
| miosis (pin point pupils) and constipation |
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Term
| head injury, pregnancy, impaired pulm/renal/hepatic function are CI to |
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Definition
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Term
| Alcohol that can cause neurotoxicity (blindness) and respiratory failure |
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Definition
| Methanol (wood alcohol) gets converted to formaldehyde |
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Term
| Ethanol -(1)-> Acetylaldehyde -(2)-> Acetic Acid. conversion mediated by |
|
Definition
1. Alcohol dehydrogenase
2. Aldehyde dehydrogenase |
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Term
| This drug inhibits acetylaldehyde dehydrogenase so you get a build up of acetylaldehyde (hangover effect) |
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Definition
|
|
Term
| what do you give for methanol poisoning? |
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Definition
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Term
| drug to give if pt ODs on a benzo? |
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Definition
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Term
| Malignant hyperthermia is due to a genetic predisposition in skM. you get and inc in free Ca in muscle cells. tx with |
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Definition
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