Shared Flashcard Set

Details

Week 4
Medchem V
15
Other
Not Applicable
01/21/2013
Click here to study/print these flashcards.

Create your own flash cards! Sign up here.

Additional Other Flashcards

 

 

Cards

Term
Topo 1 inhibitors
 Definition
Camptothecin
Term
Topo 2 inhibitors
 Definition
Anthracyclines
Term
Main toxicity of anthracyclines
 Definition

Cardiotoxicity

because of reactive O2 species
Term
What happens to Irinotecan if you have up-regulation of UDP?
 Definition

Less irinotecan

(UDP for metabolism)
Term
Anthrocycline resistance
 Definition
  • Drug pumps PDP MRP
Term
Advantage of liposomal Doxorubicin
 Definition
  • Longer half life
  • more drug in tumor 
Term
How does Idarubicin differ?
 Definition
  • Pass BBB
  • PO

(Lack of OH)
Term
Bleomycin MOA
 Definition
  • Metal binding domain
  • chelate Fe
  • (won't bind topo 2)
Term
Bleomycin toxicities
 Definition
  • Pulmonary fibrosis
Term
Enzyme that inactivates Bleomycin
 Definition
Bleomycin hydrolase
Term
Enzyme that activates Irinotecan
 Definition
CE
Term
Topo 2 inhibitor
 Definition
Inhibit ATPase
Term
Topo 2 poison
 Definition
Target DNA-protein complex
Term
Are anthracyclines cell cycle specific?
 Definition
No
Term
Anthracycline active metabolite
 Definition
Daunarubacinol 
Supporting users have an ad free experience!