Term
| Definition of Chemotherapy |
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Definition
| Use of chemical agents to control disease |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
- Genetics
- chemical/environmental exposure
- Infectious agent
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Term
| Cancer cell characteristics |
|
Definition
- Self maintained replication
- Longer survival
- Genetic instability
- Capable of inducing neoangiogenesis
- invasion & metastasis
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Term
|
Definition
time to death of any cause
gold standard* |
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Term
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Definition
| Time to first documentation of progression - deaths before progression |
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Term
| Progression free survival |
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Definition
| time to first documentation of first progression |
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Term
|
Definition
Subjects with complete response
+
Subjects with partial response |
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Term
| Obstacles to chemotherapy |
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Definition
- Normal fast growing cells
- Cytotoxicity
- Metastasis
- Tumor resistance
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Term
Cell cycle specific drugs
(General) |
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Definition
- Cell ins specific phase
- prolonged & repeated dose
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Term
Cell cycle non-specific drugs
(General) |
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Definition
- Best for rapidly dividing cells
- also for G0 (resting)
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