Term
| Plasma makes up what percent of total blood volume? |
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Definition
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Term
Erythrocytes account for ___% of total blood volume.
WBC & platelets make up ___% |
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Definition
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Term
| What are the hematopoittic tissues and organs? |
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Definition
Spleen
Lymph nodes
thymus
bone marrow
liver
reticuloendothelial System |
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Term
| When does hematopoiesis begin? |
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Definition
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Term
| Hamatopoeisis from stem cell to erythrocyte |
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Definition
Stem cell
megaloblast
erythroblast
normoblast
reticuloblast
erythrocyte |
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Term
| What is the life span of an RBC? |
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Definition
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Term
| What is it called if you have too many RBC's? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| MCV (mean corpsular value) |
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Term
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Definition
| MCH (mean corpuscular hemoglobin) |
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Term
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Definition
| MCHC (mean corpuscular hemoglobin concentration) |
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Term
| What do you look at on a CBC to decide if there is an anemia? |
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Definition
RBC
Hgb
Hct (these three make the blood indices) |
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Term
Normal RBC
Normal Hgb
Normal Hct |
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Definition
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Term
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Definition
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Term
Low RBC and/or
Low Hgb and/or
Low Hct |
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Definition
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Term
| Anemias are classified by what two features? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| The AKA for hyperchromic anemia |
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Definition
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Term
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Definition
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Term
| MC anemia based on cell size |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Chronic GI tract bloodloss |
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Term
| Microcytic hypochromic anemias will have... |
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Definition
decreased RBC and/or Hgb and/or HCT
Decreased mcv, decreased mch and decreased mchc |
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Term
| Five most common microcytic hypochromic anemias |
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Definition
1. IDA
2. CBL (an IDA)
3. Thalassemia (Coolys)
4. ACD (anemia of chronic disease)
5. ARD (renal DS) |
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Term
| What is the best way to differentiate MCHC Anemias? |
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Definition
TIBC (total iron binding capacity)
Don't forget history and clinical presentation |
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Term
| What MCHC anemias have high TIBC? |
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Definition
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Term
| What MCHC anemia has normal TIBC? |
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Definition
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Term
| What MCHC's have low TIBC? |
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Definition
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Term
| How much of the bodies iron is in the RBC line? |
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Definition
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Term
| What are the forms of storage iron? |
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Definition
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Term
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Definition
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Term
| Acute blood loss results in a ___ anemia |
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Definition
| a normocytic normochromic anemia |
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Term
| The body stores __ to __ grams of iron |
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Definition
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Term
| How much iron from your diet are you likely to absorb (%)? |
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Definition
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Term
| Normal iron loss is __ g/day |
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Definition
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Term
| Alpha thalassemia is seen primarily in people from ___ and ___. Beta thalassemia is seen primarily in people of ____. |
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Definition
| China and southeast asia mediteranian |
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Term
| Increased MCV, Normal/increased MCH, and Normal/Increased MCHC |
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Definition
| Macrocytic normochromic/hyperhromic anemias |
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Term
| What are the four differentials for MC anemias? |
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Definition
1. B12 deficiency
2. Folic acid deficiency
3. Liver disease
4. Alchoholism |
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Term
| Megaloblastic anemias are the MC anemias caused by... |
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Definition
folic acid deficiencies (50%)
B12 deficiencies (50%) |
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Term
| Nonmegaloblastic MC anemias are caused by |
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Definition
| liver disease and alchoholism |
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Term
| What is the most common category of macrocytic anemia? (megaloblastic vs nonmegaloblastic) |
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Definition
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Term
| It your MC anemia is a B12 deficiency, it is most likely due to _____ and it is called ____. |
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Definition
Lack of intrinsic factor
pernicious anemia. |
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Term
| What percent of pernicious anemia patients die of ____? |
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Definition
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Term
| 3 most common causes of B-12 deficiency |
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Definition
1. Deficiency of IF
2. Lack of gastric acid necessary to separate B-12 from binding proteins
3. Malabsorption caused by intestinal diseases |
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Term
| Lemon yellow skin, premature graying, sore tongue, and diarrhea are symptoms of |
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Definition
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Term
| Vitamin B-12 deficiency caused by gastric mucosa failure to secrete intrinsic factor |
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Definition
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Term
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Definition
Decreased production of RBC's and Platelets
Can be caused by chemotherapeutic agants, drugs, hereditary causes, radiation and infections.
Poor prognosis |
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Term
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Definition
| due to increased RBC destruction |
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Term
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Definition
Serious chronic hemolytic anemia
Often fatal before 30
Hands and feet swell
Normocytic Normochromic |
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Term
| Absolute increase in all cell types (RBC, WBC, platelets) |
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Definition
| Polycythemia Vera (primary) |
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Term
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Definition
RBC mass remains unchanged
Decrease in plasma volume |
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Term
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Definition
erythrocyte sedimentation rate
measures the rate that the RBC's settle in saline or plasma in 1 hour |
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Term
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Definition
CRP
Indicates acute inflammatory reaction
Increases sooner and returns faster than ESR |
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Term
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Definition
neutrophils
eosinophils
basophils |
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Term
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Definition
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Term
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Definition
| Combat pyogenic infections |
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Term
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Definition
| fight allergies and parasitic infections |
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Term
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Definition
| Fight parasitic infection |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
10-18 WBC's usually due to...
(5-10 is normal range) |
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Definition
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Term
| 20-30 WBC most likely due to... |
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Definition
| hot abdomen, such as appendicitis, pancreatitis etc. |
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Term
| 30-50 WBC likely due to... |
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Definition
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Term
| Segs primarily respond to... |
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Definition
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Term
| Bands primarily respond to.. |
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Definition
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Term
| Lymphocytes primarily respond to... |
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Definition
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Term
| Eosinophils primarily respond to... |
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Definition
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Term
| Inverted ratio (lymph>segs) seen in |
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Definition
Viral infections
lymphocytic leukemia
<9 year olds |
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Term
| Leukemias are classified as... |
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Definition
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Term
| Increase in immature cells is called a |
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Definition
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Term
| Presence of ___ and/or ___ suggest a leukemia is acute. |
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Definition
Blasts
Pros (promyelocytes-primitive cells) |
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Term
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Definition
unregulated accumulation of immature cells
Left shift
bleeding, splenomegaly, hepatomegaly |
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Term
Greater than 50,000 WBC yada yada yada...
5 metas, 5 myelo, 5 pros, 5 blasts |
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Definition
AML
Acute Myelocytic Leukemia
has both blast and pros |
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Term
Greater than 50,000 WBC
yada yada yada 5 E-metas, 5 E-myelo, 5 E-pros, and 5 E-blasts |
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Definition
AEL
Acute eosinophilic leukemia
rare |
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Term
Greater than 50,000 WBC
yada yada yada 5 L-blasts |
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Definition
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Term
| Presence of ____ equals hodgkin's lymphoma |
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Definition
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Term
| Malignant proliferation of plasma cells is ____. |
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Definition
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