Term
| Group characteristics of Rhabdoviridae |
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Definition
| enveloped negative-sense ssRNA bulllet shaped virus that replicates in cytoplasm |
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Term
| How is rhabdoviridae transmitted? |
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Definition
| direct contact with contaminated saliva - via bite |
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Term
| Pathogeneisis of Rhabdoviridae |
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Definition
| virus is saliva, infection of striated muscle at inoculation site, spread to peripheral nerves via neuromuscular junction |
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Term
Viremia of Rhabdoviridae
a. retrograde transporter
b. along nerves |
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Definition
a. to dorsal root ganglia
b. to other tissues like brain, kidneys, eyes, adrenal glands |
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Term
| Clinical findings of Rhabdoviridae |
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Definition
| fever, headache, malaise, nausea, vomitting, hallucinations, combativeness, muscle spasms, signs of meningitis, seizures and localized paralysis |
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Term
| Diagnosis and Prevention and Treatment of Rhabdoviridae |
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Definition
Antigen Detection
Preexposure: recommended for anyone likely to come into contact with a rabid virus - HDCV
Postexposure: physician determine if vaccine is needed |
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Term
| Arenaviridae group characteristics |
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Definition
| enveloped negative-sense ssRNA viruses that replicate in cytoplasm |
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Term
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Definition
| direct contact with contaminated rodent excreta that is imported to US by travelers |
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Term
Lassa Virus pathogenesis
what cells does it attack? Viremia? |
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Definition
infection of innate cells (DC and macrophage)
Viremia spread to virus to various organs (skin, liver, kidneys, and brain) and innate cells in those organs
Coagulation throughout body will occur |
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Term
| Symptoms of Lassa (hemorrhagic) fever |
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Definition
| high fever, severe muscle aches, skin rash, and hemorrhages |
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Term
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Definition
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Term
| Prevention and treatment of Lassa Virus |
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Definition
| rodent control and Ribavirn (IV) reduces mortality adn potential complications |
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Term
| Bunyaviridae group characteristics |
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Definition
| enveloped negative-sense ssRNA viruses that replicate in cytoplasm |
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Term
| La Cross Virus is transmitted by: |
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Definition
| infected mosquito (aedes) |
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Term
Viremia of La Cross virus is:
It invades VEC to gain access to: ________ causing:______ |
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Definition
to various sites (lymph nodes, spleen, stomach, nasal tissue)
CNS neurons causing neuronal degeneration, apoptosis, and necrosis |
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Term
| Clinical findings of La Cross Virus |
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Definition
most asymptomatic
- abrupt onset of ever and severe headache, 50% patients experience seizures |
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Term
| Hantavirus transmission is by direct contact with infected: |
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Definition
| rodents or their saliva, urine, feces, nests, or by inhalation of aerosolized virus (rodent excreta) |
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Term
| The respiratory Infection that occurs because of Hantavirus causes what pathogenesis |
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Definition
| lots of macrophages in pulmonary microvasculature and lots of DCs in follicles of spleen and lymph nodes |
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Term
Clinical Findings of Hantavirus:
a. HPS
b. HFRS |
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Definition
a. HPS: fever, myalgia, circulating immunoblasts
b. HFRS: intense headache, back/abdominal pain, fever, chills, nausea and blurred vision |
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Term
Rift Valley Fever Virus transmission:
Clinical findings:
Prevention and Treatment: |
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Definition
direct contact w/infected animal blood and body fluids (livestock) or bit by an infecte mosquito
2-6 day incubation: mild febrile illness persiting a few days
Mosquito control
vaccines available for livestock |
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Term
| Sandfly Fever Viruse transmission |
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Definition
| bite by an infected female sandfly |
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Term
| Clinical findings for Sandfly Fever Virus |
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Definition
bite --> small itching papules on skin for up to 5 days
3-6 day incubation: headache, malaise, nausea, fever, photophobia, vomiting, and myalgia |
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Term
| Group Characteristics of Filoviridae (Ebola and Marburg Virus) |
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Definition
| enveloped negative-sense ssRNA virus that replicates in cytoplasm |
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Term
| Marburg Virus and Ebola are both tranmissted by direct contact with: |
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Definition
| direct contact with blood, body fluids, and tissues of infected person or with "infected" fruit bats and monkeys |
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Term
| Clinical Findings of Marbug Virus |
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Definition
| abrupt sustained fever, severe headache, malaise and myalgia, rash, and multiple bleeding sites (vomit, feces, nose, gums) |
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Term
| Clinical findings of Ebola |
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Definition
| same as marburg + sore throat |
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Term
| Diagnosis of Ebola and Marburg |
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Definition
| PCR, Ag detection, Serology |
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Term
| Prevention and Treatment of Marburg and Ebola |
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Definition
| virus-like particle (VLP) vaccine for EBOV and MARV |
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