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| Lacunae of fully formed bone (calcified matrix) |
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| Inorganic calcium phosphate; mineralization in osteoid |
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| surround secretory glands |
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| contractile muscle cells that surround blood vessels |
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| Contract and secrete collagen in healing wounds |
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| intermediate filament in epithilial cells |
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| intermediate filament in connective tissue |
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| intermediate filament in all muscle types - part of cytoskelatin |
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| sheath that encapsulates entire muscle; continuous with muscle tendon |
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| divides muscles into individual fascicles(visible with naked eye) **contains nerves and vessle**AEROLEAR LOOSE CT |
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| delicate partition that surrounds each muscle fiber (cell) within fascicles - continuous with perimysium **contains capillaries **AEROLEAR LOOSE CT |
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| long, multinucleate cylindrical cell (100 peripheral nuclei) |
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| Components making up muscle |
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| Muscle<---fascicles<--muscle fibers (cells)<---myofibrils<---sarcomeres<---myofilaments<---actin and myosin |
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| dark, thick myosin filaments |
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Z-line
Insertion point for thin (actin) filaments
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M-line
Myosin fiber central attatchment |
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H-band
Central, light part of A band which contains no thin filaments (only myosin and central attatchment) |
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A-band
Length of think (myosin) filaments |
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I-band
Light zone between A-bands containing only thin (actin filaments0 |
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| During contraction, what muscle bands change? |
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I-band and H-band narrow as Z-lines move closer together
Sarcomere gets shorter |
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During contraction, what muscle bands do NOT change?
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| Width of A-band stays constant during contraction and stretching |
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Group of muscles suppllied by an individual nerve fiber
Can range from a few to >1000 muscle fibers |
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Specialized region of plasma membrane (sarcolemna) in which nerve terminal lies
AKA: motor end plate |
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| extension of muscle cell membrane which runs along sarcoplasmic reticulum--->carries action potential into cell so it may activate sarcoplasmic reticulum |
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complex formed where sarcoplasmic reticulum flanks t-tubule in skeletal muscles
**at junction if A-band and I-band |
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Differences between cardiac and skeletal muscle?
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Cardiac m. has:
1. Branching muscle fibers
2. 1 or 2 nuclei, CENTRALLY located
3. intercalated disks = not electrically isolated
4. involuntary, controlled by autonomic nervous system
3. no NMJs, no motor nerve control |
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| Skeletal muscle is similar to cardiac muscle |
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1. strong and foceful contractions
2. Striated, contain myofibrils and sarcomeres |
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| Branching nerve supplying a motor unit |
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Sarcoplasmic reticulum on one side or the other of a t-tubule in cardiac muscle **located at z-line |
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| Specialized myocardial fibers that conduct an electrical stimulus or impulse that enables the heart to contract in a coordinated fashion |
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| Location of smooth muscle |
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Definition
Blood vessels Intestines Uterus Respiratory tract |
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| Innervation of smooth muscle (3 things) |
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Definition
1. Autonomic nervous system 2. Hormones 3. Local metabolites
NO neurologic innervation |
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rhythmic/wave like contractions of smooth muscle **slow, low-force but long lasting contractions |
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| %bone organic and inorganic |
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| Organic component of bone |
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Definition
90%collagen 10%ground substance |
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| inorganic component of bone |
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| Hydroxyapetite (calcium phosphate) |
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| What cells secrete collagen matrix (osteoid) |
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| What cells are osteoclasts derived from? |
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| Mononuclear cells (same as macrophages) |
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| 3 times osteobprogenetor cells develop into osteoblasts |
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normal growth (young animal) fracture repair normal bone remodeling |
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| how are osteocytes connected? |
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| canaliculi - allows for transfer of waste and nutrients, coordination of response to hormones |
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| differences between chondrocytes and osteocytes |
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Definition
Chondrocytes are mitotically active and can form nests Osteocytes are NOT mitotically active and exist by themselves |
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| Osteiod or collagenous extracellular matrix - synthesized by osteoblasts |
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| what makes up cancellous bone |
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| trabeculae (thin bony projections) |
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| What cells are in compact bone |
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| Where do blood vessels run in compact bone |
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Spongy bone has haverian systems? True or False? |
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Spongy bone has lamellae? True or false? |
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| What lines trabeculae in spongy bone? |
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| What is outer layer of periosteum made up of |
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Definition
| Dense connective tissue with few cells |
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| What is inner layer of peristoeum made up of? |
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| Highly cellular - osteoblasts (embryo/young) and osteoprogenitor cells (adult) |
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| What lines all cavities of bone? |
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| endosteum - lines aversion canals and marrow spaces |
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| Thin layer of squamous cells |
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| Intramembranous ossification |
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| bone forms directly in primitive mesenchyme - does not have cartilage template |
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| What bones form via intramembranous ossification? |
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non-weight bearing bones Flat bones of skull, mandible, clavicle |
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| Endochondral ossification |
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Definition
| Bone forms on preexisting cartilage model (hyaline cartilage) |
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| What bones form via endochondral ossification? |
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| Vertebral column, pelvis, limb bones - weight bearing bones |
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| 3 steps in Intramembranous ossification |
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Definition
1. Mesenchymal condensation - mesenchymal cells secrete collagen and ground substance; fibroblasts and osteobrogenitor cells arise and trabeculae forms
2. Osteoblasts arise - osteoid is produced; some cells become entrapped and form osteocytes
3. Bone spicule formation - woven bone forms and is remodelled to lamellar bone; bone addition and removal shapes forming bone |
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| 2 Steps in endochondral ossification |
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Definition
1. Hyaline cartilage template - Cartilage mineralizes, mineralized cartilage is removed, bone is deposited
2. Ossification centers form - primary (diaphysis) and secondary (epiphyses) --> eventually develop into medullary cavities
**cartilage continues growth in physis in epiphysial plate or growth plate |
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| epineureum is made of what kind of tissue |
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Definition
| dense regular connective tissue |
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| what type of tissue is dura mater made of |
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| what structure makes up grey matter in spinal cord |
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