Term
| ______ is converted to estradiol |
|
Definition
|
|
Term
| high levels of estrogen feed back on the hypotalmus to decrease_______ |
|
Definition
|
|
Term
| Follicle develops in response to rising ___ levels |
|
Definition
|
|
Term
| the spike in ___ stimulates ovulation |
|
Definition
|
|
Term
| primary estrogen in premenpausal women |
|
Definition
|
|
Term
| primary estrogen in postmenopausal women |
|
Definition
|
|
Term
| estrogen produced during pregnancy |
|
Definition
|
|
Term
ethinyl-estradiol
mestranol
dienestrol |
|
Definition
|
|
Term
delayed onset and prolonged duration of action
aqueous solutions have rapid onset
suspensions or solutions have delayed onset and are long acting |
|
Definition
| synthetic estrogen characteristics |
|
|
Term
| clinical uses of estrogen therapy |
|
Definition
hormonal deficiency
replacement therapy
abnormal uterine bleeding
contraception |
|
|
Term
|
Definition
|
|
Term
| clinical uses of estrogen therapy |
|
Definition
hormonal deficiency
replacement therapy
abnormal uterine bleeding
contraception |
|
|
Term
|
Definition
| help menopause symptoms, prevent osteoporosis |
|
|
Term
|
Definition
| < 5 years to avoid cardivascular incidents, stoke, ovarian cancer |
|
|
Term
| When should HRT be initiated |
|
Definition
| slightly before menopause |
|
|
Term
| Drug interactions of estrogens |
|
Definition
decrease effects of anticoagulants and hypoglecemics
increase adverse effects of TCAs, increase effects of oxytocin |
|
|
Term
| this supplement may interefere with contraceptive efficacy |
|
Definition
|
|
Term
| Adverse Effects of estrogen therapy |
|
Definition
| nausea, endocrine changes, cancer, THROMBOEMBOLIC disorders |
|
|
Term
| Contraindications of Estrogen therapy |
|
Definition
| pregnancy, cardivascular disease, breast and uterine cancer, thromboembolic disease, smoking |
|
|
Term
| these are antagonists that bind to both ERalpha and ER beta |
|
Definition
| selective estrogen receptor modulators |
|
|
Term
| SERMs are used for _________ |
|
Definition
| estrogen recepto-positive cancers |
|
|
Term
| SERMs are typically metabolized by the ______ |
|
Definition
|
|
Term
| gold standard SERM that acts as an antagonist in breast tissue used to prevent breast cancer in pre-menopausal women |
|
Definition
|
|
Term
| side effects of tamoxifen |
|
Definition
| increased risk of endometrial cancer and venous thromboembolism |
|
|
Term
| contraindications of tamoxifen |
|
Definition
| selective serotonin reuptake inhibitors |
|
|
Term
| this SERM is used to prevent osteoporosis or to prevent breast cancer in high risk post-menopausal women |
|
Definition
|
|
Term
| Raloxifene should not be taken with |
|
Definition
|
|
Term
| this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women |
|
Definition
|
|
Term
| this SERM is used in the treatment metastic breast cancer for advanced-stage post menopausal women |
|
Definition
|
|
Term
| this SERm can enhance the effects of Warfarin |
|
Definition
|
|
Term
| these reduce estrogen production by inhibiting the aromatase enzyme |
|
Definition
| Aromatase Inhibitors (AIs) |
|
|
Term
Anastrozole (Armidex)
Letrozole (Femara)
Exemestane (Aromasin) |
|
Definition
| Aromatase Inhibitors (AIs) |
|
|
Term
| these are superior to SERMs in treating postmenopausal women with less risk of thromboembolic events and endometrial cancer |
|
Definition
|
|
Term
| AIs are currently used in ______ therapy |
|
Definition
|
|
Term
|
Definition
| osteoporosis, follicular growth in premenopausal women, joint pain after discontinuation |
|
|
Term
| used with estrogens for menopausal hormone replacement therapy to limit estrogen's effect on the endometrium |
|
Definition
|
|
Term
| progesterone can be used with estrogen as a ________ |
|
Definition
|
|
Term
| Mifepristone (Mifeprex RU-486) |
|
Definition
| Progesterone Receptor Modulators |
|
|
Term
| abortion pill- acts as a progesterone receptor antagonist; acts at the uterus lining; do not use for ectopic pregnancy |
|
Definition
| Mifepristone (Mifeprex; RU-486) |
|
|
Term
| this fertility drug blocks estrogen receptos and interferes with feedback increasing FSH and LH |
|
Definition
|
|
Term
| multiple births can occur r/t this fertility drug |
|
Definition
|
|
Term
| contraindications of Clomiphene citrate |
|
Definition
|
|
Term
| these fertility drugs induce follicular maturation and ovulation due to increase in both FSH and LH activity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| adverse effects of menotropins |
|
Definition
| ovarian hyperstimulation syndrome, ascites, pain, bleeding |
|
|
Term
| these fertility drugs are similar to menotropins but only exhibit FSH activity |
|
Definition
|
|
Term
|
Definition
|
|
Term
| similar in structure and action to LH thus induces ovulation by stimulating the midcycle LH surge |
|
Definition
|
|
Term
| this dopamine agonist inhibits prolactin release, increases fertility, and may cause nausea |
|
Definition
| Bromocriptin mesylate (Parolodel) |
|
|
Term
| drug of choice to stimulate uterine contraction to induce labor |
|
Definition
|
|
Term
|
Definition
| fetal distress if delivery is not imminent and can have antidiuretic effects and cause water intoxication |
|
|
Term
| these do stimulate uterine contractions but are not used to induce labor they are used to control post partum/abortion bleeding and aid in delivery of placenta |
|
Definition
|
|
Term
| side effects of ergot alokaloids |
|
Definition
| severe hypertension, cramping |
|
|
Term
| used to control postpartum hemorrhage, and stimulate smooth muscle contraction of the GI and respiratory tract |
|
Definition
| Prostaglandins (Carboprost) |
|
|
Term
| this prostaglandin promotes cervical ripening |
|
Definition
|
|
Term
| This tocolytic can delay preterm labor for 48-72 hours increase risk of muscle weakness and respiratory arrest |
|
Definition
|
|
Term
| adverse effects of magnesium sulfate |
|
Definition
| can cross the placenta, pulmonary edema, do not use in pts with myasthenia gravis |
|
|
Term
| this tocolytic stimulates B2 receptors in the uterus |
|
Definition
|
|
Term
| what is the off label use of terabutaline sulfate? |
|
Definition
|
|
Term
| terbutaline has a wide range of adverse effects including |
|
Definition
|
|
Term
| concentations of estrogens and progestins are fixed in the the pill |
|
Definition
|
|
Term
| in this contraceptive estrogen is low and fixed and progestin is low during the first week then increases two-fold over the remainder of the cycle |
|
Definition
|
|
Term
| estrogen is fixed but progestin levels vary: low-high-low |
|
Definition
|
|
Term
| gradual estrogen intake and steady progestin intake |
|
Definition
|
|
Term
| these birthcontrols have low androgenic activity and can reduce acne |
|
Definition
| ortho tri cyclen/ ortho tri cyclen low |
|
|
Term
| placebo free pill w/ 4 periods per year |
|
Definition
|
|
Term
| this birthcontrol increases the viscosity of the cervical mucous; modifies the endometrium. weakly inhibits ovulation |
|
Definition
|
|
Term
| A single capsule composed of progestin- long acting implant |
|
Definition
| subdermal implant (implanon) |
|
|
Term
| Mechanism of action hormonal IUD |
|
Definition
| supresses proliferation of endometrial lining |
|
|
Term
|
Definition
|
|
Term
| very high doses of progesterone that inhibits ovulation and effects the uterus can be used within 72 hours to prevent pregnancy |
|
Definition
|
|
Term
| Clinical uses of androgens in males |
|
Definition
| anemia, wasting, stimulate libido |
|
|
Term
| clinical uses of androgens in females |
|
Definition
| metastatic breast malignancies, stimulation of libido, can relieve some menopausal symptoms |
|
|
Term
| adverse effects of androgens in males |
|
Definition
|
|
Term
| adverse effects of androgens in females |
|
Definition
| female virilization (masculinization) effects menstruation category X |
|
|
Term
| negative effects of androgens in both sexes |
|
Definition
| stunted growth in young people |
|
|
Term
flutamide (eulexin, drogenil)
bicalutamide (casodex) |
|
Definition
| androgen receptor antagonists |
|
|
Term
| these are used to treat metastic prostate cancer and hirsutism in ladies |
|
Definition
| androgen recpetor antagonists |
|
|
Term
| this androgen receptor antagonist is less hepatotoxic than flutamide |
|
Definition
|
|
Term
| these are used to take benign prostatic hyperplasia and treat male pattern baldness |
|
Definition
| 5 alpha reductase inhibitors |
|
|
