Term
| H2 Receptor Blockers 'Rantidine' Mechanism of Action |
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Definition
| Blocks H2 receptors in parietal cells of stomach- increase gastric pH |
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Term
| H2 Receptor Blockers 'Rantidine' Indications |
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Definition
| Peptic ulcer; GERD; Hypersecretory conditions; Prevent upper GI bleed, heartburn, and acid indigestion (OTC) |
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Term
| H2 Receptor Blockers 'Rantidine' Contraindications |
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Definition
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Term
| H2 Receptor Blockers 'Rantidine' Serious Adverse Effects |
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Definition
| Neutropenia; Agranulocytosis; Thrombocytopenia; Autoimmune hemolytic or aplastic anemia RARE |
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Term
| H2 Receptor Blockers 'Rantidine' Common Adverse Effects |
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Definition
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Term
| H2 Receptor Blockers 'Rantidine' Preadministration Assessment |
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Definition
| Assess diet and smoking habits (Highly acidic and spiced food may increase symptoms, smoking aggrevates) |
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Term
| H2 Receptor Blockers 'Rantidine' Monitoring |
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Definition
| Resolution of symptoms; S/S of blood dyscrasias (sore throat, fever, bruising, fatigue) |
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Term
| H2 Receptor Blockers 'Rantidine' Key Patient Education |
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Definition
| Take daily even if no symptoms; Do not substitute OTC for prescription |
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Term
| H2 Receptor Blockers 'Rantidine' Notes |
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Definition
| Interacts with numerous drugs; Give at least 2 hours apart from antacids |
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Term
| Proton Pump Inhibitors 'Omeprazole' Mechanism of Action |
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Definition
| Suppressess the hydrogen-potassium ATPase enzyme system- increased gastric pH, decreased pepsin activity |
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Term
| Proton Pump Inhibitors 'Omeprazole' Indications |
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Definition
| Peptic ulcers; GERD; Erosive esophagitis; Chronic hypersecretory conditions |
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Term
| Proton Pump Inhibitors 'Omeprazole' Contraindications |
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Definition
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Term
| Proton Pump Inhibitors 'Omeprazole' Serious Adverse Effects |
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Definition
| May increase risk of gastric cancer with longg-term use; Decrease symptoms of gastric cancer |
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Term
| Proton Pump Inhibitors 'Omeprazole' Common Adverse Effects |
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Definition
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Term
| Proton Pump Inhibitors 'Omeprazole' Preadministration assessment |
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Definition
| Assess diet and smoking habits (highly acidic and spiced food may increase symptoms, smoking aggravates) |
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Term
| Proton Pump Inhibitors 'Omeprazole' Monitoring |
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Definition
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Term
| Proton Pump Inhibitors 'Omeprazole' Key Patient Education |
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Definition
| Take daily even if no symptoms; Take 1 hour before meals; Do not crush or chew tablet |
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Term
| Proton Pump Inhibitors 'Omeprazole' Notes |
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Definition
| Antisecretory effect lasts 24 hours; May interfere with drugs needing specific pH; Interact with drugs metabolized through cytochrome P-450 pathway (inc levels) |
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Mechanism of Action |
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Definition
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Indications |
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Definition
| Upset stomach, heart burn, symptoms associated with GERD |
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Contraindications |
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Definition
| Chronic renal failure (toxicity with repeated doses) |
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Serious Adverse Effects |
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Definition
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Common Adverse Effects |
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Definition
| Constipation (AH) Diarrhea (MH)- combination usually negates but either can occur. |
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Preadministration assessment |
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Definition
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Monitoring |
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Definition
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Key Patient Education |
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Definition
| Take 2 hours after other drugs to minimize drug interactions; not effective alone for treating peptic ulcer disease |
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Term
| Antacids Aluminum Hydroxide and Magnesium Hydroxide Notes |
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Definition
| Interacts with drugs requiring specific pH- administer 2 hours after other drugs; May bind with other drugs making them ineffective; Increases urinary pH which could affect elimination of other drugs |
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