Term
|
Definition
|
|
Term
|
Definition
| (BSA of pt/1.73)(Usual dose) |
|
|
Term
|
Definition
K1/k2
(K is rate constant) |
|
|
Term
|
Definition
| Study of energetics of a system, how it uses energy, and relative stability of components. |
|
|
Term
|
Definition
| Study of rate at which a system undergoes change. |
|
|
Term
|
Definition
| Barrier to going from reactants to products |
|
|
Term
| 1st law of thermodynamics |
|
Definition
| energy of universe is constant |
|
|
Term
deltaE=
(change in internal energy) |
|
Definition
deltaQ + deltaW
(change in heat + change in work) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Amount of disorder in a system |
|
|
Term
| what does deltaS stand for? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| How is heat capacity (Cp) defined? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| What does negative entropy indicate? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| What is deltaG at equilibrium |
|
Definition
|
|
Term
| What does negative deltaG mean? |
|
Definition
| Reaction proceeds forward |
|
|
Term
| what does negative deltaH indicate |
|
Definition
|
|
Term
What is (a) in
deltaG=nRT ln(a2/a1) |
|
Definition
|
|
Term
What is (c) in
deltaG=nRT ln(c2/c1) |
|
Definition
|
|
Term
| What is chemical potential? |
|
Definition
| The free energy per mole of substance |
|
|
Term
| in a zero order reaction what does k equal |
|
Definition
|
|
Term
| What does having a zero order mean? |
|
Definition
| the reaction rate is independent of concentration. (rate change constant) |
|
|
Term
| What does having 1st order kinetics mean? |
|
Definition
| rate of reaction is dependent on concentration. (rate changes with concentration) |
|
|
Term
| What is meant by second order kinetics? |
|
Definition
| rate of reaction involves collision of 2 molecules |
|
|
Term
| second order kinetics equation |
|
Definition
|
|
Term
| First order reaction rate law |
|
Definition
|
|
Term
| zero order reaction rate law |
|
Definition
|
|
Term
| What order reaction are suspensions? |
|
Definition
|
|
Term
| what is definition of shelf life? |
|
Definition
| time until drug decomposes to 90% of label claim |
|
|
Term
| What influences reaction rates? |
|
Definition
solvent
ionic strength
dielectric constant
pH
light
temperature |
|
|
Term
| Advantage of using Arrhenius relationship |
|
Definition
| can be tested at higher temp. |
|
|
Term
| What does the term t0.9 mean? |
|
Definition
|
|
Term
| what does X(double dagger) represent |
|
Definition
|
|
Term
| What order is the decomposition of the transition state? |
|
Definition
|
|
Term
| Are catalyst consumed in reactions? |
|
Definition
|
|
Term
| a catalyst ________ the rate reaction, and the equilibrium constant (K) ________? |
|
Definition
|
|
Term
| Hydronium ions act as an acid in _____? |
|
Definition
|
|
Term
| Hydroxide ions act as a base in _____? |
|
Definition
|
|
Term
| what is unit of second order reaction? |
|
Definition
|
|
Term
| what is the unit of first order reaction? |
|
Definition
|
|
Term
| Nucleophilic catalysis involves? |
|
Definition
| lone pairs of electons stabilizing transition state. |
|
|
Term
|
Definition
|
|
Term
| what is Keq also known as |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| molecular interaction producing a substance with properties different then reactants |
|
|
Term
| interactions of complexion can be through? |
|
Definition
Electrostatics
Dative covalent bonding
dipolar interactions
hydrogen bonding |
|
|
Term
| How can complexion affect drug performance? |
|
Definition
Increase solubility
decrease solubility
alter drug uptake
change rate of dissolution
targeted delivery |
|
|
Term
|
Definition
metal
inclusion
physical adsorption
Protein-Drug |
|
|
Term
| Primary routs of chemical inactivation |
|
Definition
|
|
Term
| Functional group most prone to hydrolysis? |
|
Definition
|
|
Term
| Which carbon is attacked in hydrolysis? |
|
Definition
|
|
Term
|
Definition
| conversion of one oxidation state to a higher oxidation state by removing electrons. (Loss of Electrons=Oxidation) LEO |
|
|
Term
| What is mechanism used during respiration and oxidative phosphorylation in animals? |
|
Definition
|
|
Term
| Three steps in free radical oxidation |
|
Definition
initiation
propagation
termination |
|
|
Term
|
Definition
E=hv
(h= 6.625 X 10^-27 v is freq in Hz) |
|
|
Term
| What can happen to molecule in excited state? |
|
Definition
Chemical reaction
energy transfer
Heat dissipation
Emission |
|
|
Term
| first order kinetic reaction slope equals? |
|
Definition
|
|
