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Tuberculosis
Therapeutics (V) Exam 3
17
Other
Not Applicable
01/25/2013
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Term

Latent TB

Therapy

(HIV)

 Definition
  • Isoniazid 300mg QD X9M
Term

Latent TB

  • Therapy (daily)

 

 Definition
  • Isoniazid 300mg QD X6M

 
Term

Latent TB

  • Therapy (INH resistant)
 Definition
  • Rifampin 300mg QD X4M
Term

Latent TB

  • Therapy (weekly)
 Definition
  • Isoniazid 900mg BIW X6-9M
Term

Active TB

  • Therapy

 

 Definition
  1. INH+ RIF + PYR + EMB X2M
  2. INH + RIF X4M
Term

INH

  • Dose
 Definition
  • 300mg
Term

RIF

  • Dose
 Definition
  • 600mg
Term

PYR

  • Dose
 Definition
  • 25 mg/kg (max 2K)
Term

EMB

  • Dose
 Definition
  • 15 mg/Kg (max 1600)
Term

PPD

  • ≥15 mm category
 Definition
No risk factors
Term

PPD

  • ≥10mm category
 Definition
  • <5 yr immigrants
  • IVDA
  • Institution
  • Children <4
  • DM
  • kidney/liver disease
  • malignancy
  • weight loss >10% IBW
Term

PPD

  • ≥5mm category
 Definition
  • HIV
  • recent contact
  • CXR
  • immunosuppressed
  • organ transplant
  • ≥15 mg/day of prednisone ≥1 month
Term
What is the only static agent?
 Definition
EMB
Term
Which drug has serious optic SE?
 Definition
EMB
Term
Which agent interacts with P450?
 Definition

INH

Inhibit

  • 2C9, 2C19, 2E1

 
Term

Seeing this triggers the change from

RIF -> Rifabutin 

 Definition
Protease inhibitor
Term
Directly observed therapy
 Definition
  • BIW
  • + sputum smears
  • treatment failure/relapse
  • substance abuse
  • MDR
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