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trueger
final MB (heme, review some chol)
51
Other
Not Applicable
05/26/2006
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Term
wheres FA synth?
 Definition
cytoplasm
Term
wheres FA burned?
 Definition
mt
Term
acCoA x 2 =
 Definition
malonylCoA, used in FA synth
Term
malonylCoA
 Definition
(acCoA x 3) then hmgcoa reductased =
Term
what makes ketones?
 Definition
HMG CoA, in liver
Term
what are the ketones?
 Definition
acetoacetate & b hydroxybutyrate
Term
where are ketones used?
 Definition
mm & brain
Term
ssx ketones?
 Definition
fruity breath (acetone)
urine does not detect b hydroxybutyrate
Term
ketones->
 Definition
2 accoa
Term
chol synth rate lim steo
 Definition
hmgCoareductase
hmg coa-> mevalonate
Term
hmgcoa=
 Definition
acacetate + ac coa = 3x ac Coa
Term
LCAT
 Definition
plasma chol est'd to lecithin chol
Term
pancr lipase
 Definition
degrs TG in sm int
Term
lipoprotein lipase
 Definition
degrs circulating chylomicrons & vldls
Term
hepatic TG lipase
 Definition
degr any TG in IDL
Term
hormone-sens lipase
 Definition
degr TG stored in adipocytes
Term
degrs TG in sm int
 Definition
pancr lipase
Term
degrs circulating chylomicrons & vldls
 Definition
lipoprotein lipase
Term
degr any TG in IDL
 Definition
hepatic TG lipase
Term
degr TG stored in adipocytes
 Definition
hormone-sens lipase
Term
steps in FA digestion
 Definition
1) TG->FFA in lumen (pancr lipase)

2)uptaken as chylomicrons (as TGs)

3)chylomicron remnant sent to liver (Tgs & FFAs)

4)VLDL: TG&ch

5)IDL:less TG, chol

LDL: chol

mod'd LDL -> plaque
Term
whats in a chylomicron
 Definition
TG
Term
whats in vldl
 Definition
tg, chol
Term
whats in ildl
 Definition
less tg, chol
Term
whats in ldl
 Definition
chol
Term
TG
 Definition
whats in a chylomicron
Term
tg, chol
 Definition
whats in vldl
Term
less tg, chol
 Definition
whats in ildl
Term
chol
 Definition
whats in ldl
Term
apolipoprotein b100
 Definition
binds ldlR
Term
apolipoprotein a1
 Definition
acts lcat
Term
apolipoprotein cii
 Definition
cofactor for lipoprotein lipase
Term
apolipoprotein e
 Definition
mediates rEmnant uptake
Term
PB poison
 Definition
inh ferrochelatase & ALA hehydrase
corproporphyrin & ALA in urine
Term
ac intermittant porphyria
 Definition
def in uroporphyrinogen I synthetase
porphobilinogen & delta ALA in urine
Term
porphyria cutanea tardia
 Definition
def in uroporhyrinogen decarb
uroporphyrin in urine = tea colored
photosens
Term
porphyria sx
 Definition
painful abd
pink urine
polyneuropathy
pysch disturbances
precip'd by drugs
Term
inh ferrochelatase & ALA hehydrase
corproporphyrin & ALA in urine
 Definition
PB poison
Term
def in uroporphyrinogen I synthetase
porphobilinogen & delta ALA in urine
 Definition
ac intermittant porphyria
Term
def in uroporhyrinogen decarb
uroporphyrin in urine = tea colored
photosens
 Definition
porphyria cutanea tardia
Term
PB poison
 Definition
inh ferrochelatase & ALA hehydrase
corproporphyrin & ALA in urine
Term
ac intermittant porphyria
 Definition
def in uroporphyrinogen I synthetase
porphobilinogen & delta ALA in urine
Term
porphyria cutanea tardia
 Definition
def in uroporhyrinogen decarb
uroporphyrin in urine = tea colored
photosens
Term
inh ferrochelatase & ALA hehydrase
corproporphyrin & ALA in urine
 Definition
PB poison
Term
def in uroporphyrinogen I synthetase
porphobilinogen & delta ALA in urine
 Definition
ac intermittant porphyria
Term
def in uroporhyrinogen decarb
uroporphyrin in urine = tea colored
photosens
 Definition
porphyria cutanea tardia
Term
heme catab
 Definition
heme-BV-BR-conj BR-intestine in bile - excreted
some is changed to urobilinogen in intest, reabs and peed as urobilin
Term
Hgb T form
 Definition
no O2
Term
Hgb R form
 Definition
O2
Term
what favors T form
 Definition
cl, h+, co2, 23bpg, temp
Term
methemoglobinemia
 Definition
binds CN- so give nitrites(mehtylene blue) in HCN poisoning
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