Term
|
Definition
low sugar diet
replace insulin |
|
|
Term
|
Definition
diet mod
exer -> wt loss
oral hypoglycemics |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| ultra-long acting insulin |
|
|
Term
|
Definition
| really long acting insulin |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| ultra-long acting insulin |
|
Definition
|
|
Term
| really long acting insulin |
|
Definition
|
|
Term
|
Definition
insR->TK
Liver: up glycogenolysis
mm:up glycogenolysis & protein synth & K uptake
fat: aids TG storage |
|
|
Term
|
Definition
type 1 DM
life-threatening hyperK & stress->hypergly |
|
|
Term
|
Definition
| hypogly, hypersens (rare) |
|
|
Term
insR->TK
Liver: up glycogenolysis
mm:up glycogenolysis & protein synth & K uptake
fat: aids TG storage |
|
Definition
|
|
Term
type 1 DM
life-threatening hyperK & stress->hypergly |
|
Definition
|
|
Term
| hypogly, hypersens (rare) |
|
Definition
|
|
Term
| what are the 1st gen sulfonylureas? |
|
Definition
tolbutamide
chlorpropramide |
|
|
Term
| what are the 2nd gen sulfonylureas? |
|
Definition
glyburide
glimepride
glipizide |
|
|
Term
|
Definition
close K channel in B cell
-> depol ->
release ins via up Ca influx |
|
|
Term
|
Definition
release eno insulin in type 2 DM
useless in DM1 |
|
|
Term
|
Definition
1st gen: disulfarim like rxn
2nd gen:hypogly |
|
|
Term
|
Definition
| dn glucogenolysis?, up gly, dn serum glu |
|
|
Term
|
Definition
| oral hypogly, even w/o islets |
|
|
Term
|
Definition
|
|
Term
|
Definition
| up target cell resp to insulin |
|
|
Term
|
Definition
up wt
heptox (trog, not used anymore) |
|
|
Term
| what are the a-glucosidase inh? |
|
Definition
|
|
Term
|
Definition
| inh BB enzymes -> deld hydrolysis -> dn postprandial hypergly |
|
|
Term
|
Definition
|
|
Term
tolbutamide
chlorpropramide |
|
Definition
| what are the 1st gen sulfonylureas? |
|
|
Term
glyburide
glimepride
glipizide |
|
Definition
| what are the 2nd gen sulfonylureas? |
|
|
Term
close K channel in B cell
-> depol ->
release ins via up Ca influx |
|
Definition
|
|
Term
release eno insulin in type 2 DM
useless in DM1 |
|
Definition
|
|
Term
1st gen: disulfarim like rxn
2nd gen:hypogly |
|
Definition
|
|
Term
| dn glucogenolysis?, up gly, dn serum glu |
|
Definition
|
|
Term
| oral hypogly, even w/o islets |
|
Definition
|
|
Term
|
Definition
|
|
Term
| up target cell resp to insulin |
|
Definition
|
|
Term
up wt
heptox (trog, not used anymore) |
|
Definition
|
|
Term
|
Definition
| what are the a-glucosidase inh? |
|
|
Term
| inh BB enzymes -> deld hydrolysis -> dn postprandial hypergly |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| obesity mgmt (w. diet mod) |
|
|
Term
|
Definition
| steatorrhea, GI discomfort, red'd ADEK, HA |
|
|
Term
|
Definition
| SNS: 5ht & NE reuptake inh |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
inh org & coupling of T4
PTU also blocks T4->T3 |
|
|
Term
|
Definition
| skin rash, agranulocytosis, aplastic anemia |
|
|
Term
| GH (somatostatin) clin use |
|
Definition
|
|
Term
|
Definition
| acromegaly, carcinoid, gastrinoma, glucagonoma |
|
|
Term
|
Definition
| stim labor, ut contrns, milk let down, controls uterine hem |
|
|
Term
|
Definition
|
|
Term
|
Definition
T3
tachy, heat intol, tremors |
|
|
Term
|
Definition
|
|
Term
|
Definition
| addisons, inflammo, immunosuppr, asthma |
|
|
Term
|
Definition
|
|
Term
| obesity mgmt (w. diet mod) |
|
Definition
|
|
Term
| steatorrhea, GI discomfort, red'd ADEK, HA |
|
Definition
|
|
Term
| SNS: 5ht & NE reuptake inh |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
inh org & coupling of T4
PTU also blocks T4->T3 |
|
Definition
|
|
Term
| skin rash, agranulocytosis, aplastic anemia |
|
Definition
|
|
Term
|
Definition
| GH (somatostatin) clin use |
|
|
Term
| acromegaly, carcinoid, gastrinoma, glucagonoma |
|
Definition
|
|
Term
| stim labor, ut contrns, milk let down, controls uterine hem |
|
Definition
|
|
Term
|
Definition
|
|
Term
T3
tachy, heat intol, tremors |
|
Definition
|
|
Term
|
Definition
|
|
Term
| addisons, inflammo, immunosuppr, asthma |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
A & B spermatogonia (2N)
->spermatocyte (dipl 4N)->soermatocyte (hapl 2N)->
spermatid (N)in sem tubules |
|
|
Term
|
Definition
| stim release of test from Leydig cells |
|
|
Term
|
Definition
differentiates male gen
anabolic on protein metab
maintains gametogenesis & libido
inh GnRH
fuses epiphyseal plates in bone |
|
|
Term
|
Definition
| stim sertoli cells to produce ABP & inhibin |
|
|
Term
|
Definition
| ensures that test in sem tubule is high |
|
|
Term
|
Definition
|
|
Term
|
Definition
| fSh -> Sertoli cells -> Spermatogen |
|
|
Term
|
Definition
| Lh -> Leydig cells -> Libido (test) |
|
|
Term
|
Definition
|
|
Term
| stim release of test from Leydig cells |
|
Definition
|
|
Term
differentiates male gen
anabolic on protein metab
maintains gametogenesis & libido
inh GnRH
fuses epiphyseal plates in bone |
|
Definition
|
|
Term
| stim sertoli cells to produce ABP & inhibin |
|
Definition
|
|
Term
| ensures that test in sem tubule is high |
|
Definition
|
|
Term
|
Definition
|
|
Term
| fSh -> Sertoli cells -> Spermatogen |
|
Definition
|
|
Term
|
Definition
|
|
Term
| where do DHT and test come from? |
|
Definition
|
|
Term
| where does andro come from? |
|
Definition
|
|
Term
|
Definition
| skin, prostate, sem ves, epididymis, liver, mm, brain |
|
|
Term
|
Definition
1) wolffian -> internal gonadal structures
2) 2nd sex chars & growth spurt
3)reqd for nl spermgen
4)anabol-> up mm size & RBC prdn
5)up libido |
|
|
Term
| adipose tissue hormonal fn |
|
Definition
| test & andro -> estr (aromatase) |
|
|
Term
|
Definition
ovary (estradiol)
placenta (estriol)
blood (aromatase) |
|
|
Term
|
Definition
| estradiol > estrone > estriol |
|
|
Term
|
Definition
growth of follice
endometrial prolif, myometr exc'y
dev of genitalia
stromal dev of breast
female fat distr
hep synth of transport proteins
feedback inh FSH
LH surge (FB on LH switches from neg->pos right before surge)
up HDL, dn LDL |
|
|
Term
|
Definition
dn hot flashes
dn bone lossbut if unopposed (no prog) -> up risk endometrial CA |
|
|
Term
|
Definition
FSH stims aromatase ->
aromatase cat: andro ->estrogen
secr estrogen |
|
|
Term
|
Definition
LH stim desmolase
desmolase cat: chol -> andro |
|
|
Term
FSH stims aromatase ->
aromatase cat: andro ->estrogen
secr estrogen |
|
Definition
|
|
Term
LH stim desmolase
desmolase cat: chol -> andro |
|
Definition
|
|
Term
|
Definition
| corpus lut, placenta, adr cortex, tested |
|
|
Term
|
Definition
stim endom gland secrns & spiral art dev
mainatain preggers
dn myom exc'y
prodn thick cerv muc (inh sperm entry into uterus)
up body temp
inh LH & FSH
ut SM relax |
|
|
Term
|
Definition
|
|
Term
| corpus lut, placenta, adr cortex, tested |
|
Definition
|
|
Term
stim endom gland secrns & spiral art dev
mainatain preggers
dn myom exc'y
prodn thick cerv muc (inh sperm entry into uterus)
up body temp
inh LH & FSH
ut SM relax |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| prolif phase, LH surge & ovulation, secr phase, mens |
|
|
Term
|
Definition
|
|
Term
| estrogens role in mens cycle |
|
Definition
| stimulates endometrial prolif |
|
|
Term
| proges role in mens cycle |
|
Definition
| maintains endometrium to support implantation |
|
|
Term
|
Definition
|
|
Term
|
Definition
| up, peaking before LH surge, another sm peak w/ proges peak in prolif phase |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| prevent estr surge -> no LH surge -> no ov |
|
|
Term
|
Definition
pain during ov
due to blood from ruptd follicle -> irrat
can mimic appy |
|
|
Term
pain during ov
due to blood from ruptd follicle -> irrat
can mimic appy |
|
Definition
|
|
Term
|
Definition
prim oocytes begin in fetal life
finish just bf ovulation |
|
|
Term
| where is meisosis 1 halted |
|
Definition
prophase
for yrs, until ov |
|
|
Term
| meisosis 2 is arrested…? |
|
Definition
|
|
Term
|
Definition
prim follicle -> oocyte ->
2nd follice (w. antrum) |
|
|
Term
|
Definition
| syncytiotrophoblast of placenta |
|
|
Term
|
Definition
maintains corpus luteum for 1st trim by acting like LH
in 2nd &3rd: placenta synth its own estr & progest & CL degensused to detect pregs: appears 8 days after successful fert elevated w. hydatidiform mole or chorioCA |
|
|
Term
|
Definition
cessation of estr prodn w. age-linked decline in number of ov folls
av onset at 51 y.o
earlier in smokers |
|
|
Term
| hormonal changes in menopause |
|
Definition
dn estr
UP FSH, up LH (w.o surge)
up gnRH |
|
|
Term
|
Definition
Hot flashes
Atrophy of Vagina
Osteoporosis
CAD |
|
|
