Term
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Definition
promyelocyte->myelocyte->
metamyelocyte->stab cell->PMN, Eo, or basophil |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
glu
90% -> lactate
10%->HMP shunt |
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Term
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Definition
Cl-HCO3 antiport->
physiologic chloride shift
alows RBC CO2 transport |
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Term
what do basophils do?
grans? |
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Definition
mediate allergic rxn
grans: heparin, histamine, LTD-4 |
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Term
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Definition
mediate allergic rxn
grans: heparin, histamine, Eo chemotactics
membrs bind IgE
Type 1 hypersense rxns
rx: cromolyn! |
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Term
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Definition
grans:major basic protein (MBP),eosinophil peroxidase (EPO)
arylsulfatase, acid phosphatase |
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Term
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Definition
| NAACP neoplastic, astyhma, allergic process, collagen vasc dz, parasites |
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Term
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Definition
hydrolytics
lysozyme
MPO
lactoferrin |
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Term
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Definition
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Term
| b12/folate def - blood finding |
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Definition
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Term
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Definition
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Term
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Definition
| intrinsic pathway (all but vii) |
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Term
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Definition
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Term
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Definition
| extrinsic pathway (ii, v, vii, x) |
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Term
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Definition
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Term
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Definition
XII-> XIIa
XIIa: XI->Xia
Xia ix->ixa
ixa + viia: x->xa |
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Term
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Definition
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Term
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Definition
xa & va: ii -> iia
iia: i->ia +xiiia -> clot |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| steps in coag that req Ca & platelet phospholipid |
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Definition
xia: ix-ixa
ixa+viiia:x->xaTF:vii->viia
viia+TF:x->xa xa+va:II->iia |
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Term
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Definition
| inact va & viiia: vit k dep |
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Term
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Definition
inacts thrombin, ixa, xa, xia
act'd by heparin |
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Term
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Definition
| generates plasmin -> cleave fibrin |
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Term
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Definition
hered sphere
autoimmune hemolysis |
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Term
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Definition
megaloblastic anemia (w/ hyperseg PMNs)
marrow failure |
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Term
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Definition
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Term
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Definition
| myeloid metaplasia w/ myelofibrosis |
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Term
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Definition
| abetalipoproteinemia w/ spiny appearance |
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Term
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Definition
HbC dz
Asplenia
Liver dz
ThalasemiaHALT |
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Term
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Definition
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Term
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Definition
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Term
| megaloblastic anemia -> rbcs? |
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Definition
| macro-ovalocytes & hyperseg PMNs |
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Term
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Definition
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Term
| myeloid metaplasia w/ myelofibrosis |
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Definition
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Term
| abetalipoproteinemia w/ spiny appearance |
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Definition
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Term
HbC dz
Asplenia
Liver dz
ThalasemiaHALT |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| etios: microcytic anemia, hypochromic |
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Definition
IDA
thalassemias
lead poisoning, sideroblastic anemias |
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Term
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Definition
dn serum iron
up TIBC
dn ferritin |
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Term
dn serum iron
up TIBC
dn ferritin |
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Definition
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Term
| etios: macrocytic anemias |
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Definition
megaloblastic
drugs that block DNA synth (sulfas, AZT) |
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Term
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Definition
| megaloblastic anemia (w/ hyperseg PMNs) |
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Term
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Definition
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Term
| normcytic, normochromic anemia etios |
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Definition
acute hem
enzyme defects (g6pdd, pk def)
RBC membr defects (hered sphero)
BM ds (aplastic anemia, leuk)
Hgbpathies (sickle)
autoimmune hemolytic anemia
anemia of chr dz (dn TIBC, up ferritin, up Fe storage in marrow macs) |
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Term
| dn serum haptoglobin & up serum LDH |
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Definition
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Term
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Definition
| immune vs non immune RBC hemolysis |
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Term
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Definition
pancytopenia w. severe anemia, dnPMN, dnPLTLTs
caused by failure or destr of multipotent SCs
etios: radn, benzen, chloramphenicol, alk agents, antiMBs, viri (parvo b19, EBV, HIV), fanconi, idiopathic (immune/prim SC), post-ac-hep |
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Term
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Definition
| fatigue, malaise, pallor, purpura, muc bleeding, petechiae, infn |
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Term
| fatigue, malaise, pallor, purpura, muc bleeding, petechiae, infn |
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Definition
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Term
| aplastic anemia path feats |
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Definition
pancytopenia w. nl cell morphology
hypcell BM w. up fat
dx: BM bx |
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Term
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Definition
| withdrawal cause, allogenic BM transplant, RBC & pltlt transfusion, G-CSF or GM-CSF |
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Term
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Definition
parvob19-> aplastic crisis
autosplenectomy
up risk encaps infn
salmonella osteomyelitis
painful/veno-occl crisis
splenic sequestration crisis |
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Term
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Definition
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Term
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Definition
diff B chain mutn
pts w. HbC or HbSC: mild sickle dz |
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Term
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Definition
no comp increase in other chains
HbH tetramers & Hb Barts -> hydrops fetalis -> fetal death |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| B4 tetr, no alpha genes at all |
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Term
| B4 tetr, no alpha genes at all |
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Definition
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Term
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Definition
| gamma4 tetramer, lack all alpha genes |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| up fetal Hb but inadequate |
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Term
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Definition
| severe anemia in b thal major reqs transfusions |
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Term
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Definition
major -> HF due to 2ndary hemochromatosis
marrow expn -> skel deforms |
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Term
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Definition
autoimmune
hered sphero
PNH
microangiopathic anemia |
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Term
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Definition
up serum BR
-> jaundice, pigm bile stones
up rtcytes (Marrow comp for anemia) |
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Term
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Definition
mostly extravasc hemolysis (kupffer & spleen)
warm agglut (igg)- chr anem seen in SLE, CLL, or rx (methyldopa)
cold aggl (igm)- acute anemia triggered by cold, post myco pneum infn or mono
erythroblastosis fetalis- seen in newborn due to Rh or other incomp |
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Term
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Definition
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Term
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Definition
anti-igabs added to rbcs
aggl ifcoated w. ig |
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Term
| indirect coombs test defn |
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Definition
nl RBCs added to pts serum
aggl if serum has anti-RBC sfc ig |
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Term
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Definition
intr, extravasc hemolysis due to spectrin or ankyrin defect
sm rnd rbcs, no central pallor
less membr -> up MCHC, up RDW |
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Term
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Definition
intravasc hemolysis due to membr defect
up sens of rbcs to lytic act'y of compl
up serum hemosidirin |
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Term
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Definition
| intravasc hemolysis seen in DIC, TTP/HUS |
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Term
intr, extravasc hemolysis due to spectrin or ankyrin defect
sm rnd rbcs, no central pallor
less membr -> up MCHC, up RDW |
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Definition
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Term
intravasc hemolysis due to membr defect
up sens of rbcs to lytic act'y of compl
up serum hemosidirin |
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Definition
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Term
| intravasc hemolysis seen in DIC, TTP/HUS |
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Definition
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Term
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Definition
obstetr (most common)
gram neg sepsis
transfusion
trauma
mailgn
acut pancr'it is
nephrotic syndrome |
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Term
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Definition
up PT, up PTT
up fibr split products(ddimers)
dn pltlts
helmet shaped RBCs and schistocytes |
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Term
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Definition
| antiplatelet Abs, up megaKs |
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Term
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Definition
| schistocytes, up LDH, neuro sx |
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Term
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Definition
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Term
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Definition
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Term
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Definition
def vWF
defect of platelt adh and dn viii survival |
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Term
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Definition
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Term
| dn platelets, up bleeding time |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| dn platelets, up bleeding time, pt & aptt |
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Term
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Definition
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Term
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Definition
| dn platelets, up bleeding time |
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Term
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Definition
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Term
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Definition
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Term
| dn platelets, up bleeding time, pt & aptt |
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Definition
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Term
| abnl bleed w. nl PT, nl PTT |
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Definition
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Term
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Definition
viii, ix, xi def (bleeding pts)
xii, preK, HMWK def (w.o bleeding) |
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Term
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Definition
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Term
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Definition
v, x, ii, I (common pathway def)
sev hep dz
DIC |
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Term
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Definition
| abnl bleed w. nl PT, nl PTT |
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Term
viii, ix, xi def (bleeding pts)
xii, preK, HMWK def (w.o bleeding) |
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Definition
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Term
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Definition
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Term
v, x, ii, I (common pathway def)
sev hep dz
DIC |
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Definition
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