Term
|
Definition
| synergistic combo of folate antagonists blocks purine production and nucleic acid synthesis |
|
|
Term
|
Definition
| bactericidal against susceptible bacteria |
|
|
Term
| TMP-SMX: clinical applications? |
|
Definition
| PCP pneumonia, UTIs, toxoplasmosis, nocardiosis |
|
|
Term
| How TMP-SMX be given? How is it cleared? What is the ratio? Tox? |
|
Definition
| oral or IV, renally, 1:5 TMP:SMX, rash, fever, BM suppression, hyperkalemia |
|
|
Term
| Sulfisoxazole: How is it given? What is it used for? |
|
Definition
|
|
Term
| Sulfadiazine: How is it given? What is it used for? |
|
Definition
| oral, toxoplasmosis (combined with pyrimethamine) |
|
|
Term
| Trimethoprim: How is it given? What is it used for? Is it safe for pts with sulfonamide allergy? |
|
Definition
|
|
Term
| Pyrimethamine: How is it given? What is it used for? What is coadministered? |
|
Definition
| oral, toxoplasmosis when combined with sulfadiazine, coadmin with leucovorin to limit BM toxicity |
|
|
Term
| Pyrimethamine-sulfadoxine: How is it given? It is second line treatment for what? |
|
Definition
|
|
Term
|
Definition
| inhibits DNA replication by binding DNA gyrase and topoisomerase IV |
|
|
Term
|
Definition
| bactericidal against susceptible bacteria |
|
|
Term
| Ciprofloxacin: clinical applications? |
|
Definition
| UTIs, gastroenteritis, osteomyelitis, anthrax |
|
|
Term
| Ciprofloxacin: How is it given? How is it cleared? What impairs absorption? Toxicity? |
|
Definition
| oral and IV, mixed clearance, di and tr-valent cations impair oral abs, tox- GI upset, neurotox, tendonitis |
|
|
Term
| Ofloxacin: How is it given? What is it used for? |
|
Definition
| oral, onkly for UTIs and non-gon urethritis and cervicitis |
|
|
Term
| Levofloxacin: How is it given? What is it used for? |
|
Definition
| oral and IV, L-isomer of ofloxacin, once daily dosing, renal clearance, "respiratory" fluoroquinolone with better activity against pseudomonas |
|
|
Term
| Moxifloxacin: How is it given? What is it used for? |
|
Definition
| oral and IV, "respiratory" fluoroquinoline, once daily dosing, better for anaerobes and TB, hepatic clearance - lower urinary levels, not used for UTIs |
|
|
Term
| Gemifloxacin: How is it given? What is it used for? |
|
Definition
| oral, "respiratory fluoroquinolone" |
|
|
