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Toxicities and Side Effects
Boards
40
Pharmacology
Professional
05/04/2010
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Term
Anti-Muscarinic
 Definition
Tricyclics (Amitryptiline)
Term
Coronary Vasospasm
 Definition
Cocaine, Sumatriptan (5HT1D blocker)
Term
Cutaneous Flushing
 Definition
Niacin, Vancomycin, Adenosine, Ca2+ Channel blockers
Term
Dilated Cardiomyopathy
 Definition
Doxo/Daunorubicin (prevent with Desrazoxane)
Term
Torsades de Pointes
 Definition

Class 1a ant-arrhythmics (quinidine, procainide, disopyramide)

-Class III (Sotalol, Bretylium, ibutilide, Amiodarone)

-Cisapride (5HT4 agonist- ^ GI motility)
Term
Agranulocytosis
 Definition
Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole
Term
Aplastic Anemia
 Definition

-Chloramphenicol

-Benzene

-NSAIDS

-Propylthiouracil, Methimazole
Term
Direct Coombs-positive hemolytic anemia
 Definition
Methyldopa
Term
Gray Baby Syndrome
 Definition
Chloramphenicol
Term
Hemolysis in G-6-PD deficiency
 Definition

-Malaria drugs (Primaquine)

-Sulfonamids

-Isoniazid

-Aspirin

-Ibuprofen

-Nitrofurantoin (ab for UTI)
Term
Megaloblastic Anemia
 Definition

-Methotrexate

-Phenytoin

-Sulfa drugs
Term
Cough
 Definition
ACE inhibitors
Term
Pulmonary Fibrosis
 Definition
Amiodarone, Busulfan, Bleomycin
Term
Acute Cholestatic hepatitis
 Definition
Macrolides
Term
Massive Hepatic Necrosis
 Definition
Acetaminophen, Halothane, Phalloides Mushroom, Valproate
Term
Hepatitis
 Definition
Isoniazid
Term
C. Diff infection
 Definition
Clindamycin, Ampicillin
Term
Adrenocortical insufficiency
 Definition
Glucocorticoid withdrawal
Term
Gynecomastia
 Definition

Spironolactone, Digitalis, Cimetidine, Alcohol, Ketoconazole

Some Drugs Create Awesome Knockers
Term
Hot Flashes
 Definition
Tamoxifen, Clomiphene (anti-estrogens)
Term
Gingival Hyperplasia
 Definition
Phenytoin
Term
Gout
 Definition
Thiazide diuretics, Furosemide
Term
Osteoporosis
 Definition
Corticosteroids, Heparin
Term
Photosensitivity
 Definition
Sulfonamides, Amiodarone, Tetracycline
Term
Rash (Steven's Johnson)
 Definition
Penicillin, Lamotrigine, Sulfa drugs, Ethosuximide, Carbamazepine, Phenobarbital, Phenytoin, Allopurinol
Term
SLE-like syndrome
 Definition
Procainide, Hydralazine, Isoniazid, Phenytoin
Term
Tendonitis/Tendon rupture
 Definition
Fluoroquinolones
Term
Fanconi's sydrome
 Definition
Expired Tetracyclines
Term
Interstitial Nephritis
 Definition
 Methicillin, NSAIDS, Furosemide
Term
Hemorrhagic Cystitis
 Definition
Cyclophosphamide, ifosfamide
Term
Cinchonism
 Definition
Quinidine, Quinine
Term
Diabetes Insipidus
 Definition
Lithium, demeclocycline
Term
Parkinson-like syndrome
 Definition

Potent Typical Anti-Psychotics (Haloperidol, Fluphenazine)

-Reserpine

-Metoclopramide

 
Term
Seizures
 Definition
Bupropion, imipenem/cilastatin, isoniazid
Term
Bisulfiram-like rxn
 Definition

Metronidazole, Procarbazine (anti-neoplastic alkalater), 1st generation sulfonylureas (Telbutamide, Chlorpropamide)

 
Term
Nephro/Oto toxicity
 Definition
Aminoglycosides, Vancomycin, Loop diuretics, cisplatin (protect w/ amifostine)
Term
P450 inducers
 Definition

Quinidine

Barbiturates

St. John's Wort

Phenytoin

Rifampin

Griseofulvin

Carbamazepine

 
Term
P450 Blockers
 Definition

Ketoconazole

Erythromycin

Grapefruit Juice

Sulfonamides

Isoniazid

Cimetidine

Ritonivir

Ciprofloxacin
Term
Sulfa drugs
 Definition
Celecoxib, Furosemide, Probenicid, thiazides, TMP-SMX, sulfasalazine, sulfonylureas, sumatriptan
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