Controls how quickly the body burns energy, makes proteins, and controls how sensitive the body should be to other hormones.

Which is more common, hypothyroidism or hyperthyroidism?

Hypothyroidism is more common and can occur in all age groups.

[image][image][image][image]Wikipedia: hypo definition: hypochondria. →

thyroid - stimulating hormone (TSH) stimulates the secretion of thyroxine (T4), which is converted to T3 (which is 4x more potent than T4).

T4 inhibits the secretion of TSH; thus a negative feedback loop is created.

Describe the hormone levels in hypothyroidism

Hashimoto's Disease, an autoimmune condition in which a patient's antibodies attack their thyroid gland.

[image][image][image][image]

Low free thyroxine (FT4): normal range 0.8 - 3.0 uIU/mL

High thyroid stimulaitng hormone (TSH): normal range 0.3 - 3.0 uIU/mL

[image][image][image][image]

Levothyroxine is FDA pregnancy category A. Pregnant women with thyroid hormone deficiency or TSH elevation during pregnancy may have children at risk of impairment in their intellectual function and motor skills. Pregnancy women being treated with thyroid hormone replacement require a 30 - 50% increase in the levothyroxine dose.

T4

Though, T4 is ultimately converted to T3 (the more active form)

once-daily dosing, is inexpensive, and has more uniform potency

Basically, take this medication by itself seperate from other medications due to drug interactions that decrease the drugs absorption.

On an empty stomach with a full glass of water 30 minutes before breakfast.

tachycardia, arrhythmias, heart failure and osteoporosis.

No on should be using thyroid hormone to lose weight - they will be irritable (obnoxious) and can end up with severe cardiac complications.

Grave's disease; which tends to occur in females in the 30s and 40s. It's an autoimmue disease in which one's own antibodies stimulate the thyroid gland.

Destorying all or part of the gland via radioactive iodine (RAI - 131) or surgery.

Symptom control (to reduce palpitations, tremor and tachycardia).

PTU or _______ can be used as a temporary measure untill surgery is complete (in hyperthyroidism).

inhibit synthesis of thyroid hormone by blocking the oxidation of iodine in the thyroid gland; PTU also inhibits peripheral conversion of T4 to T3.

liver damage, be seen at once if develop yellow skin, hih fever, or severe sore throat.

Caution in pregnant women (preg cat D): PTU for women trying to conceive or in 1st trimester - change to methimazole for 2nd and 3rd trimesters.

Main shortcomming: have to be taken for life, if stopped at all symptoms reappear - for this reason most get more permanent treatment (surgery).

Statement. Not a question.

Thyroid storm is rare but serious and can happen in patients with hyperthyroidism, due to a particularly stressful event (infection, MI, diabetes, childbirth) and occasionally due to lack of treatment. It can also be due to extreme emotional stress. Thyroid storm can be fatal; patients with hyperthyroidism will need to try and live as stree - free as possible and should be able to recognize the symptoms of thyroid storm. They should understand that this is a medical emergency.

Fever (> 103 degrees F)

Tachycardia

Tachypnea

Profuse sweating

Agitation

Psychosis

Coma