Term
|
Definition
| rod shaped, slow growing, aerobic bacteria |
|
|
Term
| What does TB infection depend on? |
|
Definition
| intimacy, duration of contact, degree of infectiousness, host defences |
|
|
Term
| What is happens after being infected with TB? |
|
Definition
Remain dormant, activated;
Reach alveoli, multiply in alveoli macrophages, lysis;
Ingested by monocytes;
Bacteria replicate causing specific immune reactions causing tissue damage (tubercles) |
|
|
Term
|
Definition
| latent organism overcomes immunological control and starts replicating |
|
|
Term
| What is primary progressive TB? |
|
Definition
| failure to control initial replication after initial infection |
|
|
Term
|
Definition
| TB affecting more than one site |
|
|
Term
| What is the Mantoux test? |
|
Definition
Identify those at high risk of developing TB from latent infection
Intradermal injection of TB purified protein derivative (PPD), watch for delayed type reation, measure diameter |
|
|
Term
| What is the standard short course treatment for 6 months? |
|
Definition
Ioniazid, Rifampcin, Pyrazinamide, Ethambutol
|
|
|
Term
| What TB drug is requires monitoring visual acuity? |
|
Definition
|
|
Term
| How does ethambutol work? |
|
Definition
| prevents incorporation of mycolic acid in bacterial cell wall |
|
|
Term
|
Definition
| inhibits bacteria RNA polymerase |
|
|
Term
|
Definition
| interferes with biosynthesis of mycolic acids (for cell wall) |
|
|
Term
| Babies of nursing mothers on ioniazid therapy should be given what? |
|
Definition
| pyrodoxine 5mg on days mothers take INH |
|
|
