Term
| tissue grafted from your leg to your breast is called what type of graft |
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Definition
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Term
| tissue transplanted from one identical twin to the other is called what kind of graft |
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Definition
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Term
| tissue graft from genitically different members of the SAME species is called |
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Definition
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Term
| most common graft transplant for humans involving kidenys, hearts, lungs, liver and bone marrow is ___ grafts |
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Definition
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Term
| grafts between different species is called |
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Definition
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Term
| name the three groups of Ag that serve as transplant antigens |
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Definition
1. major histocompatiblity antigens
2. Minor histocmpatiblity antigens
3. ABO Antigens |
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Term
| are there MHC antigens on RBC |
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Definition
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Term
| after multiple pregnancies there are Ab formed to paternal ___ |
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Definition
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Term
| what mechamism of rejection has the largest contribution |
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Definition
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Term
| why would Ab usually not be as importnat in aucte rejection |
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Definition
| if there is no pre-existing Ab to the donor Ag then it cant play as much a role in acute rejection |
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Term
| if you lack a thymus then you can't have what kind of graft rejeciton |
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Definition
| then no allograft rejection |
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Term
| does it take a lot of damage to graft to cause rejection |
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Definition
| NO. only takes a few graft cells to be dammaged to cause rejeciton |
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Term
| large accumulation of __ and ___ in a graft is inidciative of Delayed type hypersensitivity and graft reejction |
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Definition
1. Macrophages
2. T lymphocytes |
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Term
| If you suspected DTH of a graft what would you look for on the graft |
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Definition
| large amount of macrophages and T lymphocytes. |
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Term
| bone marrow tx are also called |
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Definition
| hematopoietic stem cell tx |
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Term
| what is the difference between allogenic and autologous bone marrow tx |
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Definition
1. Allogenic Bone Marrow Tx
- graft from genetically diff members of same species
2. Autologous Bone Marrow Tx
- just like autologous transfusions. Person donates own bone marrow before chemo destroys their own. |
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Term
| Explain Graft Versus Host Disease |
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Definition
Donor T cells attack recipient. The donor T cells will activate either to the recipients
1. MHC Ag
or
2. Mino Histocompatibility Ag |
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Term
| what organs are primarily affected by graft versus host disease 3x |
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Definition
1. liver
2. skin
3. intestine |
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Term
| How do we avoid graft vs host disease 2x |
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Definition
1. MHC Typing
2. immunosuppression therapy to suppress DONOR T cells |
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Term
| a major concern and s/e of bone marrow tx is |
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Definition
| graft versus host disease. Those with weak immune systems can fall victim to T cells from the donor graft. |
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