Term
| Eicosanoids are important for? 2x |
|
Definition
1. inflammation
2. cellular signalling |
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Term
| which COX is important for normal gastric mucosa and influences kidney funciton |
|
Definition
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|
Term
| Which COX enzyme do we want to target |
|
Definition
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Term
| Explain the prostaglandin mechanism of action |
|
Definition
| prostaglandin act on gproteins that activates adenylcyclase which then increases intracellular cAMP. cAMP activates PKA. PKA causes decreasd free |
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Term
| T/F do you need a normal balance of prostaglandins to maintain platelet activity and coagulation |
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Definition
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Term
| What type of surgery would you be worried about for prostacylcin release? What are the Sx? |
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Definition
| Bowel surgery like mesenteric traction. Causes large release of prostacyclins which can vasodilate, and inhibit platelet aggregation. Results in flushing of face, hypotension, increased HR and sweating. |
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Term
| What are the four effects of nonsteroidals |
|
Definition
1. analgesia
2. anti-inflammatory
3. antipyretic
4. platelet inhibition |
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Term
| What is the mechanism of action of nsaids |
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Definition
| inhibits cyclooxygenase activity which results in the decrease in peripheral synthesis of prostaglandins. By decreasing porstaglandin synthesis we decrease the inflammation associated with it. It also helps with pain and decreases nociception. |
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Term
| toradol (ketorolac) is contraindicated in what kind of patients |
|
Definition
| pts with peptic ulcer disease |
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Term
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Definition
Aspirin can induce asthma in 8-20% of people. Its related to the release of leukotrienes. People at greatest risk have these three risk factors:
1. rhinosinusitis
2. nasal polyps
3. asthma
Its life threatening and often occurs 1-3 hours after taking it. |
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Term
| Histamine is primarily found where? |
|
Definition
1. Mast Cells
2. Basophils
3. Enterochromaffin like cells (ECLs)
4. some neurons |
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Term
| What are the key signs most noticable during anesthesia for anaphylaxis or anaphylactoid? |
|
Definition
1. hives
2. bronchoconstriction (peak airway pressures)
3. hypotension |
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Term
| Treatment for anaphylaxis |
|
Definition
1. 100% FiO2
2. Epi IV or IM at 0.01-0.5
3. Intubate if necessary
4. IV fluids 1-2 liters LR wide open
5. Benadryl 50-75 mg IV
6. Pepcid: 20mg IV
7. Vassopressor (EPI) gtt if needed.
8. Steroids |
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