Term
| what receptors do atropine and scop block? |
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Definition
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Term
| you pair atropine with what AcHe Inhibitor |
|
Definition
| Atropine goes with edrophonium |
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|
Term
| glycopyrrolate pairs with what two drugs? |
|
Definition
1. neostigmine
2. pyridostignmine |
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|
Term
| with large doses of anticholinergics what sx occur |
|
Definition
| inhibits micturition, gastric Hydrogen ion secretion and gut motility. |
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|
Term
| adult dose of atropine in the OR is? |
|
Definition
| 0.4mg IV. For a code its 1mg. do no exceed 3mg. |
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|
Term
| pedi dose for atropine is? |
|
Definition
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|
Term
|
Definition
| half life of 2-4 hours, can cross BBB, high doses can cause CNS effects such as restlessness, delirium, coma, renal excretion, |
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|
Term
| IM Atropine dose adult? Pedi? |
|
Definition
adult 1-2mg
pedi 20-40mcg kg |
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|
Term
| does atropine increase or decrease baroreflex? explain |
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Definition
| it decreases, b/c since atropine increases your HR it also increases your blood pressure. The baroreflex normally regulates this by decreasing your HR when it senses increase BP. So atropine disables this |
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|
Term
| Does atropine cross the placenta |
|
Definition
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|
Term
| why does atropine increase your risk for emesis? |
|
Definition
| it lowers the tone to your lower esophageal sphincter tone |
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|
Term
| which is more sedating atropine or scop |
|
Definition
| scop. so dont give to elderly |
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|
Term
| which is ok to give to pt with glaucoma |
|
Definition
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|
Term
| overdose of atropine or scop will result in these sx |
|
Definition
1. dilated pupils
2. dry mucosa
3. dry flushed skin
4. head ache
5. increased HR
6. blurred vision
7. ataxia
8. restlessness
9. coma |
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|
Term
| what drug can you give to treat an anticholinergic overdose. What dose? |
|
Definition
| physostigmine b/c it can cross the BBB, 1mg IV. Benzo for seizures, ventilator support if needed. |
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Term
| what is central anticholinergic syndrome? trt with? |
|
Definition
| similar to atropine overdose except pt is motionless and depression is set in. decrease resp drive, treat with physostigmine 1mg IV |
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|
Term
| whats the mneumonic for anticholinergic toxicity |
|
Definition
| ANTICHOLINERGIC TOXICITY FROM ATROPINE: blind as a bat, mad as a hatter, red as a beat, hot as hades, dry as a bone, bowel and bladder loose their tone, and the heart runs alone. |
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|
Term
| whats the conc of neo + gly. |
|
Definition
| for every 1mg of neostig given 0.2 glyc |
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|
Term
| Which anticholinergic is most likely to cause emesis..why |
|
Definition
| glyc, can cause b/c it decreases the lower esophageal tone. |
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|
Term
| name a anticholinergic drug used for parkinsonianism |
|
Definition
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|
Term
| meperidine and benadryl share what in common? |
|
Definition
| both are antimuscarinic. (hence the CNS since they also act centrally) |
|
|
Term
| what is cogentin used for? |
|
Definition
| It is an anticholinergic used for alzheimers, treats also extrapyrimidial side effects from reglan or other antipsychotics |
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|
Term
| how does atropine and scop effect the resp |
|
Definition
| bronchodilation, decreases airway resistance and blunts the hyperresponsiveness of respt tracts, also decrease mucous secretion |
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