Term
| What immunity recognizes Ag |
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Definition
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Term
| Chemotactic molecules do what |
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Definition
| they direct movement of immune cells (phagocytes and lymphocytes) toward area of inflammation |
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Term
| is inflammation part of innate or adaptive immunity |
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Definition
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Term
| Innate immunity is able to recognize Ag via two ways |
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Definition
1. Complement receptors
2. Pattern recognition receptors (membrane, soluble and intracellular PRR's) |
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Term
| _____ are molecules in cell walls of microorganisms or inside of microorganisms |
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Definition
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Term
| This acute phase protein binds to LPS |
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Definition
| CRP and LPS-binding protein (LBP) |
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Term
| This acute phase protein is made in the liver and activates the ____ complement pathway |
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Definition
| lectin-complement pathway |
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Term
| What two soluble PRR can bind as oposonins and also activate the lectin complement system? |
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Definition
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Term
| What complement component can bind directly to LPS and apoptic cells |
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Definition
| C1q. then binds to CD91 on phag cells |
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Term
| Which toll-like receptor binds to LPS and works with CD14 and LBP |
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Definition
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Term
| What PRR receptor class function is phagocytosis |
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Definition
| Scavenger receptors SR-A, SR-B |
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Term
| This ___ serves as a receptor for hep C virus and some parasite entry |
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Definition
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Term
| An example of a C-type lectin receptor (CLR) is? |
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Definition
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Term
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Definition
| activating intracellular signaling pathways for transcription and secretion of inflammatory mediators. |
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Term
| NOD receptors are ___ type of PRR |
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Definition
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Term
| NOD receptor stands for ? |
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Definition
NOD
N: nucleotide-binding
O: Oligomerization
D: Domain |
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Term
| NOD receptors recognize products of bacteria such as? |
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Definition
| peptidoglycans of gram + or intracellular |
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Term
| healthy cells exhibit ____ which binds receptors on macrophages and ____ phagocytosis |
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Definition
| Healthy cells exhibit CD47 which inhibit phagocytosis by macrophages |
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Term
| NK cells kill with these three things |
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Definition
1. granzymes
2. perforins
3. IFN-gamma |
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Term
| in which type of inflammation is neutrophils first to migrate |
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Definition
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Term
| what three molecules migrate to injury |
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Definition
1 neutrophils
2. monocytes
3. lymphocytes |
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Term
| what six things promote chemotaxis |
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Definition
1. C3a
2. C5a
3. PAF
4. fibrinopeptides
5. LT-B4
6. PG (Prostacycline) |
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Term
| name 7 vasoactive meidators |
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Definition
1. histmaine
2. serotonin
3. PAF
4. bradykinin
5. prostaglandin (E2)
6. Leukotrienes LTC4, LTD4, LTE4
7. Fibrinopeptides |
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Term
| These three cytokines are released by macrophages which travel to the brain and cause the pituitary to release ___ which does what? |
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Definition
| IL-1, IL-6, TNF alpha stimulated pituitary to release ACTH. ACTH then stimulates the adrenal cortex to secrete cortisone to damper inflammatory response. |
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Term
| NK and TH1 cells both secrete ____ which activates macrophages |
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Definition
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Term
| Chronic inflammation is contributed to by what two cytokines |
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Definition
IFN-gamma (th-1 and NK cells)
TNF-alpha (macrophages) |
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Term
| delayed type hypersensitivity cells part of adaptive immune system are also known as |
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Definition
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Term
| two examples of passive immunity |
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Definition
1. breast feeding
2. antibody transfusion |
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Term
| vaccinations are an example of passive or active immunity |
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Definition
| ACTIVE b/c you are exposued to inert pathogen that your body has to do all the work to develop a fighting force against |
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Term
| hematopoietic growth factors do what? Give two examples |
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Definition
hematopoietic growth factors regulate proliferation in bone marrow.
1. erythropoietin
2. colony-stimulating factor |
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Term
| Name morphological characteristics of apoptosis |
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Definition
1. chromatin condensation
2. fragmentation of DNA
3. decrease cell volume
4. plasma membrane blebbing
5. cell fragments and eaten
6. death of cell |
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Term
| what cytokine accelerates apoptosis |
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Definition
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Term
| What unique flag is exhibited on surface of cells wanting to be destroyed? What immune cells have soemthing to recognize this and kill them |
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Definition
| Dying cell exhibits FAS protein. T cytoxic cells have a FAS ligand that can recongize this and carry out attack |
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Term
| During apoptosis or necrosis is there release of digestive enzymes |
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Definition
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Term
| the enzyme for starting ROS pathway |
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Definition
|
|
Term
| hematopoietic growth factors do what? Give two examples |
|
Definition
hematopoietic growth factors regulate proliferation in bone marrow.
1. erythropoietin
2. colony-stimulating factor |
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|
Term
| Name morphological characteristics of apoptosis |
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Definition
1. chromatin condensation
2. fragmentation of DNA
3. decrease cell volume
4. plasma membrane blebbing
5. cell fragments and eaten
6. death of cell |
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|
Term
| what cytokine accelerates apoptosis |
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Definition
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Term
| What unique flag is exhibited on surface of cells wanting to be destroyed? What immune cells have soemthing to recognize this and kill them |
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Definition
| Dying cell exhibits FAS protein. T cytoxic cells have a FAS ligand that can recongize this and carry out attack |
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Term
| During apoptosis or necrosis is there release of digestive enzymes |
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Definition
|
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Term
| the enzyme for starting ROS pathway |
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Definition
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Term
| Components of O2 independent kill of phags |
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Definition
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Term
| ____ cells most commonly found in tissues |
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Definition
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Term
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Definition
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Term
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Definition
| they are a littel bit of both a NK cell and T cell. They have TCR that are specific, not diverse. Look for pathogens with CD1 (NOT MHC)Also have CD16 on surface. |
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Term
| The accessory molecule associated with the BCR membrane |
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Definition
| an Ig-alpha and Ig-beta dimer |
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Term
| the two unique things on NK cells |
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Definition
CD-16: identifies NK and some other cells
CD-16: IgG FcReceptor
CD56: N-CAM. IDentifies when other cells lack enough number of MHC 1. |
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Term
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Definition
1. dendritic cells
2. macrophages
3. B cells
4. endothelial cells |
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Term
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Definition
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Term
| IGA found where principally |
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Definition
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Term
| only antibody that crosses into placent |
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Definition
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Term
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Definition
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Term
|
Definition
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Term
| The variable region of each heavy chain is approximately 110 amino acids long and is composed of a single Ig domain. |
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Definition
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