Term
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Definition
| Fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds |
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Term
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Definition
| Erythematous raised patches with adherent keratotic scaling and follicular plugging; atrophic scarring may occur in older lesions |
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Term
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Definition
| Rash as a result of unusual reaction to sunlight, by patient history or physician observation |
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Term
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Definition
| Oral or nasopharyngeal ulceration, usually painless, observed by a physician |
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Term
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Definition
| Nonerosive arthritis involving two or more peripheral joints, characterized by tenderness, swelling, or effusion |
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Term
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Definition
Pleuritis—convincing history of pleuritic pain or rub heard by a physician or evidence of pleural effusion, or
Pericarditis—documented by electrocardiogram or rub or evidence of pericardial effusion |
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Term
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Definition
Persistent proteinuria >0.5 gm/dL or >3 if quantitation not performed or
Cellular casts—may be red blood cell, hemoglobin, granular, tubular, or mixed |
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Term
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Definition
Seizures—in the absence of offending drugs or known metabolic derangements (e.g., uremia, ketoacidosis, or electrolyte imbalance), or
Psychosis—in the absence of offending drugs or known metabolic derangements (e.g., uremia, ketoacidosis, or electrolyte imbalance) |
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Term
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Definition
| Hemolytic anemia—with reticulocytosis, or Leukopenia—<4.0e9 cells/L (4000 cells/mm3) total on two or more occasions, or Lymphopenia—<1.5e9 cells/L (1500 cells/mm3) on two or more occasions, or Thrombocytopenia—<100e9 cells/L (100e3 cells/mm3) in the absence of offending drugs |
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Term
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Definition
Anti-DNA antibody to native DNA in abnormal titer, or Anti-Sm—presence of antibody to Sm nuclear antigen, or Positive finding of antiphospholipid antibodies based on
(1) an abnormal serum level of IgG or IgM anticardiolipin antibodies,
(2) a positive test for lupus anticoagulant using a standard test, or
(3) a false-positive serologic test for syphilis known to be positive for at least 6 months and confirmed by negative Treponema pallidum immobilization or fluorescent treponemal antibody absorption test |
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Term
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Definition
| An abnormal titer of antinuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs known to be associated with drug-induced lupus syndrome |
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