Term
| factors that affect a drug's ADME |
|
Definition
-solubility
-size
-route of administration
-functional groups |
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|
Term
| drug characteristics that favor absorption |
|
Definition
-uncharged
-nonpolar
-right pka and right ph
-low mw
-lipid soluble |
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Term
|
Definition
| drug is eliminated unchanged in urine, bile, exhaled air, sweat, breast milk, and saliva |
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Term
|
Definition
| drug is changed to facilitate elimination in urine and bile |
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Term
|
Definition
| removal of drug from plasma. sum of excretion and biotransformation. |
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Term
|
Definition
| drugs are foreign substances |
|
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Term
|
Definition
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Term
|
Definition
| transferases, GSH conjugase, alcohol/aldehyde dehydrogenase, hydrolytic enzymes, and other oxidative enzymes |
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Term
|
Definition
| >40% of the same amino acids |
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Term
|
Definition
| > 60% of same amino acids |
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|
Term
|
Definition
| members of a subfamily that each have 60% of the same amino acids |
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Term
|
Definition
| phenobarbital, rifampin, tobacco |
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Term
|
Definition
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|
Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
|
Definition
| barbituates, rifampin, st. john's wort |
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Term
|
Definition
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|
Term
|
Definition
| fluconazole, ketoconazole |
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| ketoconazole, itraconazole, fluconazole, cimetidine, grapefruit juice |
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