Term
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Definition
| response measured on a continuous scale |
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|
Term
| competitive antagonists shirt the Dr curve |
|
Definition
| to the right without affecting maximum response |
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Term
|
Definition
| effect cannot be overcome by more drug |
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|
Term
| the move the curve is shifted to the right |
|
Definition
| the longer the tissue has been incubated with irreversible antagonist |
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|
Term
| receptor reserve/spare receptors |
|
Definition
-max effect does NOT require occupation of all receptors by agonist
-low conc. of irreversible antagonists may bind and a max response can still be achieved
-receptor number exceeds the effectors available
-receptor number and effector number can vary between tissues |
|
|
Term
| in the presence of spare receptors |
|
Definition
-Kd is higher than E50
-needs LESS than 50% of receptors occupied to achieve 50% of max response |
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Term
|
Definition
| change in potency, not efficacy |
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|
Term
| noncompetitive antagonists |
|
Definition
| -change in efficacy not potency |
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|
Term
| noncompetitive antagonist in the presence of spare receptors |
|
Definition
| potency and efficacy change |
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|
Term
| quantal dose response curves |
|
Definition
-response is an either/or event
-related dose and frequency of response in a population of individuals |
|
|
Term
|
Definition
-quantifies the safety margin of a drug in a population of people
-TD50/ED50 |
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