Term
| This is an analogue of sulfonamide |
|
Definition
|
|
Term
| Where must the S atom be linked to to be essential? |
|
Definition
| directly to the benzene ring |
|
|
Term
| what are the most potent sulfonamide structurally? |
|
Definition
| heterocyclic rings substituted on the N |
|
|
Term
| sulfonamide mech of action |
|
Definition
| inhibit bacterial dihydropteroate synthase which eventually prevents tetrahydrofolate |
|
|
Term
| What is a result of THF deficiency |
|
Definition
| inhibits thymidine and purine synthesis thus interfering w/ DNA replication |
|
|
Term
| why is it that sulfonamides dont kill mammailian cells? |
|
Definition
| bacteria lack a folate transporter, whereas mamm cells can be rescued if exogenous folate is available |
|
|
Term
| resistance to sulfonamides |
|
Definition
overproduction of PABA
mutation in dihydropteroate synthase
expression of a transport system |
|
|
Term
| type of organism treated by sulfonamide |
|
Definition
|
|
Term
| Sulfisoxazole/Erythromicin |
|
Definition
| used for otitis media in children |
|
|
Term
| used in treatment for nocardiosis. toxoplasmosis? |
|
Definition
sulfisoxazole and sulfamethoxazole
in comb. w/pyrimethamine, an inhibitor of DHF reductase |
|
|
Term
| second line streatment of malaria |
|
Definition
| sulfamethoxazole in comb. w/trimethoprim |
|
|
Term
| adverse effects of Sul/TMP |
|
Definition
hypersensitivity
urinary obstruction
hematopoietic disturbance |
|
|
Term
| Trimethoprim mech of action, comb w/sulf? |
|
Definition
inhibits bacterial DHF reductase
bacteriocidal together |
|
|
