Term
| what is retinoic acid synthesized from? |
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Definition
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Term
| the nuclear receptor superfamily has structural domains for what |
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Definition
| ligand binding, DNA binding, and trascriptional activation |
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Term
| what inactivates the GC receptor |
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Definition
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Term
| What happens when GC binds to its receptor? |
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Definition
| it displaces Hsp90 and translocates to the nucleus where it coactivated on the DNA by HAT |
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Term
| when the ligand binds to the receptor what happens to the complex? |
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Definition
| there is a conformational change and the Hsp is released, causing the DNA binding site on the recetpor to be exposed |
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Term
| what is the function of the SHBG? |
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Definition
| increases the half life of the steroids in the extracellular space prior to entry |
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Term
| why does the primary response to steroid hormones NOT involve signal amplification? |
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Definition
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Term
| In ligand independent DNA binding, where is the receptor? |
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Definition
| bound to DNA even in absence of ligand, but with a corepressor on it |
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Term
| How does gene transcription occur in ligand independent DNA binding? |
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Definition
| the ligand binds to the receptor already placed on the DNA |
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Term
| what is the effect of non traditional steroid receptor DNA binding |
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Definition
| the binding of a hormone to different RE's to facilitate selective receptor modulation of gene transcription, in response to binding by different ligands with various agonistic and antagonistic activities. |
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Term
| what does non-traditional steroid receptor DNA binding and Transcription involve? |
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Definition
| ligand dependent interaction with the steroid receptor |
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Term
| Non-traditional steroid receptors is classeified by what? |
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Definition
| binding to DNA at sites other than SRE's |
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Term
| what is the function of SERM? |
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Definition
| create unique conformational change in the receptor to target specific co-factor binding and alteration of gene transcription. |
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Term
| what does idoxifene interaction with the E2 receptor |
|
Definition
| exposes regions of the receptor that allows it to bind to ERE |
|
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Term
| what is Raloxefine's effect on Estrogen receptors? |
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Definition
| it does NOT exposes receptor to binding of ERE. It instead exposes the ER receptor to the RRE |
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Term
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Definition
| from arginine (via no synthase) |
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Term
| what is the effect of Nitroglycerin |
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Definition
| It is converted to NO, which increases blood flow to the heart |
|
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Term
| what is the pathway of NO activating to guanylyl Cyclase |
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Definition
| Ach->Calmodulin->NO->guanylyl cyclase |
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Term
| what two things do cGmP activate |
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Definition
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Term
| What effect does atrial natriuretic peptide have on guanylyl cyclase? |
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Definition
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Term
| what is the effect of light activation on PDE and GMP signaling? |
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Definition
| it activates transducin, which activates phosphodiesterase leading to deactivation of cyclic GMP |
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Term
| what are examples of eicosanoids? |
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Definition
| prostaglandins, prostacyclin, thromboxanes, and leukotrienes |
|
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Term
| how are eicosanoids synthesized? |
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Definition
| through arachidonic acid (made by PLA2) |
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Term
| arachidonic acid is converted to prostaglandin by what enzyme? |
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Definition
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Term
|
Definition
| release of normal prostaglandins |
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Term
|
Definition
| production of more prostaglandins due to inflammation |
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|
Term
| Prostaglandin secretion happens by |
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Definition
| excitatory neurotransmitter Glutamate |
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Term
| what is the signalling pathway for Prostaglandins |
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Definition
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