Term
|
Definition
| mechloroethamine, anthracyclines |
|
|
Term
| IV, Intra-arterial, Intrathecally and oral administration routs |
|
Definition
|
|
Term
| IV and oral administration |
|
Definition
| cyclophosfamide, epipodopyllotoxins (oral is only 50% bioavail) |
|
|
Term
| prevents multidrug resistance in tumor seen with anthracyclines |
|
Definition
| verapamil; inhibits active transport by inhibiting ATP binding causing a dysfunctional pump |
|
|
Term
| irreversible cardiotoxicity |
|
Definition
| doxorubacin, daunorubacin |
|
|
Term
| metal chelating agent that binds Fe/OH product used to mitigate anthracycling-associated cardiotoxicity |
|
Definition
|
|
Term
| Used to treat mitomycin-induced Hemolytic-uremic syndrome |
|
Definition
| catopril, heparin and prednisone |
|
|
Term
| FH2 rescue after high dose methotrexate |
|
Definition
|
|
Term
| 6-MP-induced hyperuricemia |
|
Definition
| lower dose and add allopurinol, no dose adjustment for 6-TG |
|
|
Term
|
Definition
| mechloroethamine, anthracyclines (mitoxantrone less so), mitomycin, and vinca alkaloids |
|
|
Term
| albumin-bound paclitaxel dosage form option for taxane-induced HS |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| cisplatin/ carboplatin and methotrexate (precipitation of 7OH metabolite) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| doxorubacin (daunorubacin), carboplatin |
|
|
Term
|
Definition
| methotrexate, cytarabine, 6-MP (6-TG less so) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| alkylating agents and cisplatin |
|
|
Term
|
Definition
| antimetabolites, except 5-FU |
|
|
Term
|
Definition
| non-phase specific because it acts on both the DNA and RNA |
|
|
Term
|
Definition
|
|
Term
| cell cycle non-specific but maximal kill in G1 and S-phase |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| taxanes; paclitaxel and docetaxel |
|
Definition
|
|
Term
|
Definition
| metabolite of CTP-11 (irinotecan) that is 1000-fold more potent, if there is mutation in conjugation step of metabolism this metabolite is not excreted causing toxicity |
|
|
