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Definition
| any foreign substance taken into the body, it may produce beneficial effects or they may be toxic |
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| Substances that produce adverse biological effects |
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| Toxic metabolites of an xenobiotic |
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| Specific proteins produced by living organisms that exhibit acute (immediate) effects |
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| Toxicants that cause immediate death or illness when exposed to small amounts |
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| Drugs can be classified by- |
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Definition
Source
chemical formula
mode of action
therapeutic use
system acted upon |
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Definition
| A chemical substance that has actions on living tissue |
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| amount of xenobiotic encounted in the environment |
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Definition
| The actual amount of the exposed dose that enters the body |
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| Dose which is administered |
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| Factors affecting bio availability |
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Definition
| Absorption, Distribution, Metabolism, Excretion |
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Definition
| pertains to the elimination or ejection of the xenobiotic substance and its metabolites by specific excretory organs |
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| pertains to the removal of the absorbed xenobiotic substances and its metabolites by the metabolism |
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Definition
| most xenobiotics introduced into the body undergo chemical changes which render them less toxic |
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Definition
| most xenobiotics introduced into the body undergo chemical changes which render them more toxic after biotransformation |
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| changes the chemical structure and proberties of chemical comounds |
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Definition
| reduction, hydrolysis, oxidisation, hydration, isomerisation, dehalogenation |
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Definition
| Some products of phase 1 metabolism and conjugated to hyrophillic side groups |
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| Score of how often journal articles are cited in other publications |
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