Term
| Structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artificial ventilation. Full doses lead to respiratory paralysis and require ventilation |
|
Definition
| Neuromuscular blocking drugs |
|
|
Term
| These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB) |
|
Definition
| Inhaled anesthetics, especially isoflurane, aminoglycosides, and antiarrhythmic |
|
|
Term
| These prevent the action of ACh at the skeletal muscle endplate to produce a "surmountable blockade," effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine) |
|
Definition
| Nondepolarizing type antagonists |
|
|
Term
| Agent with long DOA and is most likely to cause histamine release |
|
Definition
|
|
Term
| Non-depolarizing antagonist has short duration |
|
Definition
|
|
Term
| Agent can block muscarinic receptors |
|
Definition
|
|
Term
| Agent undergoing Hofmann elimination (breaking down spontaneously) |
|
Definition
|
|
Term
| One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis, causes muscle pain postoperatively and myoglobinuria may occur |
|
Definition
|
|
Term
| During Phase 1 these agents worsen the paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine |
|
Definition
| Cholinesterase inhibitors |
|
|
Term
| MOA of non-depolarizing drugs |
|
Definition
| Act at Nicotinic receptors by competing with ACh |
|
|
Term
| Initial effect of Depolarizing Drug |
|
Definition
|
|
Term
| Characteristics of NM blocking drugs |
|
Definition
| highly polar, poorly lipid soluble |
|
|
Term
| Causes hypotension due to histamine release |
|
Definition
| Tubocurarine and Mivacurium |
|
|
Term
| Causes cardiac arrhythmias when with halothane anesthetics; Stimulates Autonomic cholinoreceptors (Negative inotropic and chronotropic) |
|
Definition
|
|
Term
| Adverse effects of depolarizing agents |
|
Definition
| Hyperkalemia, Increased intraocular pressure, increased gastric pressure and muscle pain |
|
|
