Term
| Mechanism of Action (MOA) |
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Definition
| The manner in which molecular targets are affected by the drug (How does the drug work?) |
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Term
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Definition
| The end points of the signal transduction events (What does the drug do?) |
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Term
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Definition
| Predictable reactions, some are merely bothersome |
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Term
| Adverse Effects/Adverse Drug Reactions |
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Definition
| Anything that causes the patient to stop taking the drug |
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Term
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Definition
| Medications and health conditions that pose considerable risk |
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Term
| 4 Major Types of Drug-Receptors |
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Definition
Ion Channels
G-protein coupled receptor
Transmembrane with enzyme intracellular receptor
Intracellular receptor |
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Term
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Definition
| The concentration at which the drug elicits 50% of its maximal response |
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Term
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Definition
| Elicits a response from tissue |
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Term
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Definition
| The drug with the greatest pharmacological effects |
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Term
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Definition
| Effects are less than full agonist |
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Term
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Definition
| Causes an effect opposite to that of the agonist |
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Term
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Definition
| Prevention of activity of an agonist |
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Term
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Definition
| Binds at the same site on the receptor as the agonist |
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Term
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Definition
| Binds at a different site than the agonist |
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Term
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Definition
| Can bind at a different site than the agonist even when the agonist is bound. |
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Term
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Definition
| Tendency to bind receptors |
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Term
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Definition
| The ability to initiate a response |
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Term
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Definition
| Capacity of a single drug-receptor complex to evoke a response |
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Term
| Allosteric Model of Drug Action |
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Definition
Receptors exist in more than one configuration.
Certain percentage are in the active conformation.
Agonist can 'push' the receptors into an active conformation.
Antagonist can 'push' into an inactive conformation. |
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