Term
| A light alkali metal available in carbonate slow-release, and controlled-release forms. |
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Definition
| Lithum. It replaces sodium in the body. |
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Term
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Definition
| Has more then 3 bipolar cycles/year. This is then treated with antiepileptics NOT lithium |
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Term
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Definition
| antipsychotics = antischizophrenics |
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Term
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Definition
| The PROPHYLAXIS of recurring relapsing mania. Manic depressives, recurrent depression. Treatment of aggressive or self-mutilating behavior. Prophylaxis of schizoaffective disorder in COMBINATION withan antipsychotic depot prep. |
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Term
| What does lithium do different from sodium in neurons? |
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Definition
| Lithium can support a single action potential. It cannot maintain membrane potentials due to inadequate concentration gradient. This proves to be toxic to nervous tissues so it has a very narrow therapeutic index. |
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Term
| What are some components of a Pre Lithium work up? |
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Definition
| Creatinine, BUN, Urine specific gravity, electrolytes and lithium, ECG, CBC + Differential, T4, TSH, Pregnancy. |
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Term
| Why might Lithium not be a good idea for children or adolescents? |
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Definition
| Li may substitute for Na+ in bone which can leads to structural problems. Bones must be monitored. |
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Term
| Why do you co-administer Lithium with CPZ? |
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Definition
| The full therapeutic effect takes weeks to establish so chlorpromazine is given to fix the manic issue until the Li kicks in. |
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Term
| MOA of Lithium. Note Turnbull will not test this because it is not well understood. |
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Definition
| 1. Decreased post-synaptic receptor sensitivity. 2. Stimulates Na+ exit from cells. 3. INHIBITS cAMP AND IP3 |
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Term
| Common adverse effects of lithium. |
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Definition
| Initially N/V/D. Xerostomia. FIND HAND TREMOR. WEIGHT GAIN. THIRST. DIABETES INSIPIDUS. GOITER. |
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Term
| Some toxic symptoms of Lithium. |
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Definition
| Renewal of N/V/D. Coarse tremor. Ataxia. Albuminura. ACUTE INTERSTITIAL NEPHRITIS. |
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Term
| Why is Lithium contraindicated in patients with Sick Sinus Syndrome? |
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Definition
| It will cover up sinus bradycardia, SA Block, or Wenckebach. |
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Term
| What are the alternatives to Lithium? Very Good and Calm? |
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Definition
| Valproate, Carbamazepine, Gabapentin. Also Lamotrigine |
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Term
| What type of bipolar patient would you prescribe alternatives to lithium? |
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Definition
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Term
| Describe the adverse effects and toxicity of lithium. Hint the answer is a picture. |
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Definition
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Term
| What hormone should be monitored during lithium use? |
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Definition
| TSH. Lithium may cause hypothyroidism. |
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Term
| How would you treat lithium toxicity? |
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Definition
| Diuretics. Do NOT use thiazides because they will INCREASE the plasma levels of the drug. You can also use sodium bicarb. |
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