Term
| Pro-drug; 6-MP --> inhibits purine synthesis |
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Definition
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Term
| Nitrogen mustard; alkylates nucleic acids--> cross-links strands of DNA/RNA |
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Definition
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Term
| Inhibits calcineurin --> blocks production and release of IL-2 and inhibits T-cell activation |
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Definition
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Term
| Uncertain. May inhibit WBC migration and impair complement-dependent antibody responses |
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Definition
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Term
| prodrug; M1 (Active metabolite) inhibits DHODH --> blocks pyrimidine synthesis |
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Definition
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|
Term
| inhibits DHFR --> block purine synthesis |
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Definition
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Term
| uncertain. may inhibit collagenase activity in synovial tissue or inhibit MMPs (prevents WBC migration) |
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Definition
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|
Term
| Uncertain. Reduces IgM rheumatoid factor and immune complexes. May depress T-cell activity |
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Definition
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Term
| Uncertain. Metabolized to sulfapyridine and mesalamine by gut flora. Mesalamine (5-ASA) inhibits local prostaglandin syntehsis |
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Definition
| sulfasalazine, enteric coated |
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Term
| uncertain. may inhibit phagocytosis and lysosomal stabilization when taken up by macrophages |
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Definition
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Term
| uncertain. may modulate IL-2 and IL-2 receptors --> blocks T-cell activation |
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Definition
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Term
| Binds glucocorticoid receptors --> blocks leukocyte infiltration, inhibits synthesis of inflammatory mediators, and reduces humoral responses |
|
Definition
| prednisone, prednisolone, dexamethasone |
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Term
| reversibly inhibits COX-1 and 2 --> reduces prostaglandin synthesis, blocks chemotaxis, and alters WBC activity |
|
Definition
| diclofenac, ibuprofen, indomethacin, naproxen |
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Term
| human IgG specific for TNF-alpha; blocks TNF-alpha --> inhibits proinflammatory pathways |
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Definition
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Term
| Fab fragment of humanized IgG specific for TNF-alpha; blocks TNF_alpha --> inhibits pro-inflammatory pathways |
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Definition
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Term
| TNF receptor- IgG fusion protein; blocks TNF-alpha --> inhibits pro-inflammatory pathways |
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Definition
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|
Term
| human IgG specific for TNF-alpha; blocks TNF-alpha --> inhibits pro-inflammatory pathways |
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Definition
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|
Term
| chimeric IgG specifc for TNF-alpha; blocks TNF-alpha --> inhibits pro-inflammatory pathways |
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Definition
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|
Term
| blocks IL-1 receptors--> inhibits various inflammatory pathways |
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Definition
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Term
| humanized IgG specific for IL-6 receptor; blocks Il-6 receptors --> inhibits pro-inflammatory pathways |
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Definition
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Term
| CTLA4-IgG fushion protein; blocks CD80 and CD86 costimulation on APCs --> blocks optimal T-cell activation |
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Definition
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|
Term
| chimeric IgG specific for CD20; blocks CD20 on B-cells --> induces complement-dependent B-cell cytotoxicity |
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Definition
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|
Term
| A reduced form of folic acid; supplies cells with the necessary cofactor for purine synthesis without utilizing DHODH for reduction |
|
Definition
| leucovorin, levoleucovorin |
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