Term
| What is the most common chronic inflammation? |
|
Definition
|
|
Term
|
Definition
| invasive region of the snyovium that erodes into cartiledge and bone |
|
|
Term
| What type of immunoglobins are usually present in RA? and which is associated with higher systemic complications |
|
Definition
1) usually IgM
2) IgG associated with systemic complications |
|
|
Term
| What is clinical manifestation characteristic of most RA patients? |
|
Definition
| stiffness, especially in the AM which lasts for >30 min. |
|
|
Term
| people with RA have an increased risk for what? |
|
Definition
| malignancy: lymphoma, luekemia, multiple myeloma |
|
|
Term
| What is a common manifestation of RA in hands outside of joint swelling |
|
Definition
|
|
Term
| What is common manifestation of the elbow and shoulders |
|
Definition
| synovitis of the elbow joint and inflammation and nodules in the olecranon bursa |
|
|
Term
| What part of the spine is involved in RA? |
|
Definition
|
|
Term
| What is the most common extra-articular manifestation of RA? |
|
Definition
| Rheumatoid nodules - areas exposed to pressure |
|
|
Term
| What is the most frequent ocular manifestation of RA? |
|
Definition
|
|
Term
| What is the most common lung manifestation? |
|
Definition
| pleurisy with effusion-RF usually present |
|
|
Term
|
Definition
| RA with splenomegaly, leukopenia, and skin ulcers |
|
|
Term
| What is a vascular hallmark of early RA? |
|
Definition
| vasculitis in small synovial vessels |
|
|
Term
What is the most specific test for RA?
What is the most sensitive test for RA? |
|
Definition
1) specific CCP antibodies
2) sensitive RF antibodies |
|
|
Term
| synovial fluid findings in RA? |
|
Definition
1) straw-colored, turbid
2) neutrophils
3) low/normal glucose levels |
|
|
Term
|
Definition
| Start with NSAIDS, rapidly add methotrexate, add-on sulfasalazine, antimalarial, leflunomide, and TNF inhibitor |
|
|
Term
| What is the most pharamcologic treatment for RA? |
|
Definition
|
|
Term
| What is the MOA of abatacept and rituximab |
|
Definition
biological agents
1) abatacept: blocks T cell activation
2) rituximab: B cell targeted therapy |
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