Term
|
Definition
GnRH analog
pulsatile --> agonist
continuous --> antagonist! |
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Term
| weird indication for testosterone |
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Definition
| after burn or injury (stimulate anabolism) |
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
| 5alpha-reductase inhibitor |
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Term
| flutamide (and indication) |
|
Definition
testosterone receptor antagonist
admin with leuprolide to prevent LH increase due to decreased neg feedback
prostate cancer |
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Term
|
Definition
| inhibits desmolase (anti-androgen -- tx PCOS hirsutism, causes gynecomastia/amenorrhea) |
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Term
| spironolactone (indication, side effects) |
|
Definition
| inhibits steroid binding (anti-androgen -- tx PCOS hirsutism, causes gynecomastia/amenorrhea) |
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Term
|
Definition
| SERM -- partial agonist in hypothalamus --> decreased neg feedback --> increased FSH/LH --> ovulation |
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Term
|
Definition
SERM
anti -- breast
pro -- bone, endometrium (endometrial cancer), cardiovascular (DVTs) |
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Term
|
Definition
SERM
anti -- breast, endometrium
pro -- bone, cardiovascular (DVTs) |
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Term
| do you ever give estrogen replacement alone? |
|
Definition
| NO!! increased risk of endometrial cancer |
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Term
|
Definition
| progesterone receptor antagonist |
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Term
|
Definition
| progesterone receptor antagonist |
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Term
|
Definition
|
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Term
|
Definition
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|
Term
| SERMs -- better for pre- or post-menopausal women?? |
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Definition
| post-menopausal -- no estrogen to compete with!! |
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Term
|
Definition
|
|
Term
| what progestins do (in OCPs) |
|
Definition
1) thicken cervical mucus
2) inhibit endometrial prolif (used to tx endometrial cancer) |
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Term
|
Definition
| alpha1 agonist (selective for 1A/D on prostate; not 1B on vascular receptors) |
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Term
|
Definition
inhibit phosphodiesterase --> increased cGMP
impaired blue-green color vision!! |
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Term
|
Definition
inhibit phosphodiesterase --> increased cGMP
impaired blue-green color vision!! |
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Term
|
Definition
partial agnoist at androgen recpetors --> decreased FSH/LH
used for hereditary angioedema!! |
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Term
|
Definition
| viable sperm for 3 months!! |
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