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Renal Tubules
Things absorbed/secreted, drugs, and ion channels etc
59
Medical
Undergraduate 2
06/03/2015
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Term
Simple squamous or cuboidal cells
 Definition
Proximal convoluted tubule (PCT)
Term
Apical cell surface with brush border
 Definition
Proximal convoluted tubule (PCT)
Term
Basal cytoplasm abundant in mitochondria
 Definition
Proximal convoluted tubule (PCT)
Term
No brush border
 Definition
Distal convoluted tubule (DCT)
Term
No canaliculi or lyososomes
 Definition
Distal convoluted tubule (DCT)
Term
Apical cytoplasm has canaliculi, pinocytotic vesicles, and lysosomes
 Definition
Proximal convoluted tubule (PCT)
Term
Not part of the nephron
 Definition
Collecting duct
Term
Contains macular densa cells
 Definition
Juxtaglomerular apparatus (JGA)
Term
Contents are monitored by the macular densa cells
 Definition
Distal convoluted tubule (DCT)
Term
Acetazolamide targets this area
 Definition
Proximal convoluted tubule (PCT)
Term
Carbonic anhydrase inhibitors (eg azetazolamide) target this area
 Definition
Proximal convoluted tubule (PCT)
Term
Reabsorbed = Na/H2O (65%)
 Definition
Proximal convoluted tubule (PCT)
Term
Reabsorbed = HCO3- (80-90%)
 Definition
Proximal convoluted tubule (PCT)
Term
Reabsorbed = Glucose (almost all)
 Definition
Proximal convoluted tubule (PCT)
Term
Reabsorbed = Amino acids (almost all)
 Definition
Proximal convoluted tubule (PCT)
Term
Secreted = Acids
 Definition
Proximal convoluted tubule (PCT)
Term
Secreted = Bases
 Definition
Proximal convoluted tubule (PCT)
Term
Secreted = Drugs
 Definition
Proximal convoluted tubule (PCT)
Term
Secreted = H+
 Definition
Proximal convoluted tubule (PCT)
Term
Reabsorbed = H2O (10%)
 Definition
Thin descending limb in Loop of Henle
Term
Reabsorbed = Na+
 Definition
Thin ascending limb in Loop of Henle
Term
Reabsorbed = Cl-
 Definition
Thin ascending limb in Loop of Henle
Term
NO H2O reabsorbed
 Definition
Thin ascending limb in Loop of Henle
Term
Reabsorbed = Na/Cl/K (20-25%)
 Definition
Thick ascending limb in Loop of Henle
Term
Reabsorbed = HCO3- (5-10%)
 Definition
Thick ascending limb in Loop of Henle
Term
Hypotonic filtrate
 Definition
Thin ascending limb in Loop of Henle
Term
Reabsorbed = Na/Cl
 Definition
Distal convoluted tubule - early/promixal
Term
Reabsorbed = Na+
 Definition
Distal convoluted tubule - late and cortical
Term
Reabsorbed = Cl-
 Definition
Distal convoluted tubule - late and cortical
Term
Reabsorbed = HCO3-
 Definition
Distal convoluted tubule - late and cortical
Term
NO H2O reabsorbed
 Definition
Distal convoluted tubule - late and cortical
Term
Reabsorbed = H2O (with ADH)
 Definition
Collecting ducts
Term
Secreted = K+
 Definition
Distal convoluted tubule - late and cortical
Term
No active Na+ reabsorption
 Definition
Thin descending limb in Loop of Henle
Term
Loop diuretics (eg Frusemide) affect this part
 Definition
Thick ascending limb in Loop of Henle
Term
Thiazide diuretics affect this part
 Definition
Distal convoluted tubule (DCT)
Term
Na+ channel blocking (K+ sparing, eg amioloride) diuretics affect this part
 Definition
Principal cells of distal convoluted tubule
Term
Aldosterone receptor antagonist (K+ sparing, eg amioloride) diuretics affect this part
 Definition
Principal cells of distal convoluted tubule
Term
Na/K ATPase active transport antiport basolaterally
 Definition
Proximal convoluted tubule (PCT)
Term
Na/H+ antiport
 Definition
Proximal convoluted tubule (PCT)
Term
Na/Cl antiport
 Definition
Distal convoluted tubule - early/promixal
Term
Na/H antiport
 Definition
Distal convoluted tubule - early/promixal
Term
H+ATPase pump
 Definition
Principal cells of distal convoluted tubule
Term
Na/K ATPase basolateral antiport
 Definition
Principal cells of distal convoluted tubule
Term
Secreted = Acid
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Secreted = H+
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Secreted = Cl-
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Cl/HCO3 basolateral antiport
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Reabsorbed = K+
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Reabsorbed = HCO3-
 Definition
Alpha intercalated cells of distal convoluted tubule
Term
Secreted = Base
 Definition
Beta intercalated cells of distal convoluted tubule
Term
Secreted = HCO3-
 Definition
Beta intercalated cells of distal convoluted tubule
Term
Reabsorbed = Cl-
 Definition
Beta intercalated cells of distal convoluted tubule
Term
Cl/HCO3 luminal antiport
 Definition
Beta intercalated cells of distal convoluted tubule
Term
Mannitol (osmotic diuretic) targets this area
 Definition
Glomerulus
Term
Aldosterone works by inserting Na+/K+-ATPase pumps in basolateral membrane here
 Definition
Collecting duct
Term
Angiotensin II stimulates reabsorption of Na+ in this location
 Definition
Proximal convoluted tubule (PCT)
Term
Atrial natriuretic peptide (ANP) acts on this area to decrease Na+ reabsorption
 Definition
Collecting duct
Term
85-90% of HCO3- reabsorption occurs here
 Definition
Proximal convoluted tubule (PCT)
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