Term
| What is the mechanism of Glucocorticoids |
|
Definition
Decrease Cytokine Production
Decrease Immuno Proliferation
Decrease Phospholipase A2 Activity |
|
|
Term
| What is the mechanism of Azathiaprine |
|
Definition
|
|
Term
| What is the Mechanism of Mycophenolate |
|
Definition
Inhibits IMPDHII (Guanine Synthesis)
Required for lymphocytes (only De Novo) |
|
|
Term
| What is the mechanism of Cyclosporin A |
|
Definition
| Binds Cyclophilin to inhibit Calcineurin, preventing Il-2 Production |
|
|
Term
| What is the mechanism of Tacrolimus |
|
Definition
Macrolide
Binds Calcineurin with 10-100x's more potency than Cyclosporin A |
|
|
Term
| What is the mechanism of Sacrolimus (Rapamycin)? |
|
Definition
| Binds FKBP blocking mTOR to prevent IL-2 induction promoting a stagnant G1 phase |
|
|
Term
| Mechanism of action of OKT3 |
|
Definition
| CD3 Antibody reducing t-cell counts |
|
|
Term
| What is the mechanism of ATG or ATL? |
|
Definition
| Polyclonal Antibodies to T-cell and lymphocytes respectively |
|
|
Term
| What is the mechanism of Daclizumab |
|
Definition
Anti-CD25 Antibody
Only affects activated t-cells |
|
|
Term
| What is the mechanism of Belatacept |
|
Definition
| IgG1 linked to CTL-4 (CD28) blocking costimulation |
|
|
Term
| Adverse Effects of Glucocorticoids |
|
Definition
Cushings
Osteoporosis
Cataracts
Peptic Ulcer
Infection |
|
|
Term
| What are the adverse effects of Azathioprine |
|
Definition
High Dose->Hepatotoxic
Allopurinol decreases degradation |
|
|
Term
| What are the adverse effects of Cyclosporin A |
|
Definition
Nephrotoxic
Neurotoxic
Hepatotoxic
HPTN
Hyperlipidemia
P450 induction
Viral Infection, Lymphoma |
|
|
Term
| Side effects of Tacrolimus |
|
Definition
*Worse than Cyclosporin A
Nephrotoxicity
Neurotoxicity
Hepatotoxicity
HPTN
Hyperlipidema
P450 |
|
|
Term
| Side Effects of Sirolimus (Rapamycin) |
|
Definition
Decreased Wound Healing
Thrombocytopenia
Hepatotoxic
Hyperlipidemia
|
|
|
Term
| What are the side effects of OKT3 |
|
Definition
| Cytokine Release Syndrome |
|
|
Term
| Which Immunosuppressives are cleared by the P450 system |
|
Definition
| Cyclosporin A ,Tacrolimus, Sirolimus |
|
|
Term
| Typical Immunosuppressive regimen for transplantation preparation |
|
Definition
|
|
Term
| Typical immunosuppresive regimen to prevent Acute Rejection |
|
Definition
Calcineurin Inhibitor and
Cell Cycle Inhibitor and/or
Steroids |
|
|
Term
| What are the uses of IGIV |
|
Definition
Low Dose: Humoral Deficiency
High Dose: Asthma, Autoimmune, Kawasaki |
|
|
Term
| What is the Rho Ig used for |
|
Definition
| Prevent maternal Rho sensitization of a Rho(-) mother to her Rho(+) fetus |
|
|
