Term
| what does the distal convoluted tubule secrete? |
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Definition
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Term
| how much sodium does the DCT reabsorb? |
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Definition
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Term
| What are the special cell types called in the late DCT and the cortical collecting tubule? |
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Definition
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Term
| How much salt is reabsorbed in the cortical collecting tubule? |
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Definition
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Term
| what kind of cells (surrounding afferent arteriole) sense BP? What do they release when BP is low? |
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Definition
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Term
| what does renin activate? |
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Definition
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Term
| What part of the RAAS system stimulates thirst? |
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Definition
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Term
| where does angiotensinogin come from? |
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Definition
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Term
| What hormone does angiotensinogen II act upon? |
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Definition
| Vasopressin (to retain water) **remember renin is released in response to low BP |
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Term
| what does angiotensin II do to smooth muscle in arterioles? |
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Definition
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Term
| where does reabsorption of sodium (influenced by aldosterone) take place? |
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Definition
| principal cells of cortical collecting tubule |
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Term
| how does aldosterone work? *hint steroid |
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Definition
| affects gene regulation>>produces proteins that promote sodium reabsorption |
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Term
| High levels of K+ stimulate the release of... |
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Definition
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Term
| 3 substances that decrease sodium reabsorption: |
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Definition
| prostaglandins, bradykinins, and NO |
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Term
| Water reabsorption is CONTROLLED by: |
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Definition
|
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Term
| normal rate of water reabsorption: |
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Definition
|
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Term
| what does ADH do to middle and outer collecting duct cells? |
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Definition
| put aquaporins in>>increases permeability to water |
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Term
| ADH promotes the recycling of: |
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Definition
| urea (urea moves out into interstitial space, water follows, causes urine to be concentrated and hypertonic) |
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|
Term
| where is potassium secreted? |
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Definition
| only in cortical collecting tubule |
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Term
| what is main basic function of diuretics |
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Definition
| to block sodium reabsorption |
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Term
| how do CA inhibitors work and what disease are they used for |
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Definition
block the transport of bicarbonate out of proximal convoluted tubule>>less sodium reabsorption
glaucoma |
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Term
| How do Loop-diuretics work (Lasix)? |
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Definition
| inhibit sodium-potassium-chloride cotransporter |
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Term
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Definition
| inhibit sodium-chloride transporter in the distal tubule |
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