Term
| Treat night terrors and sleep walking with ___ |
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Definition
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Term
| Treat narcolepsy with ___ |
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Definition
| stimulants (amphetamines, modafinil) and sodium oxybate (GHB) |
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Term
| What α-amanitin is found in and what it does |
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Definition
Found in death cap mushrooms
inhibits RNA polII (can't make mRNA) and causes liver failure |
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Term
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Definition
| inhibits ribonucleotide reductase |
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Term
| MOA of 6-mercaptopurine (6-MP) |
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Definition
| blocks de novo purine synthesis |
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Term
| MOA of 5-fluorouracil (5-FU) |
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Definition
| inhibits thymidylate synthase (decreases dTMP) |
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Term
| MOA of methotrexate (MTX) |
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Definition
| inhibits dihydrofolate reductase (decreases dTMP) |
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Term
|
Definition
| Inhibits bacterial dihydrofolate reductase (decreases dTMP) |
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Term
| Treat orotic aciduria with ___ |
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Definition
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Term
|
Definition
| bind 30S subunit (a ribosomal subunit in prokaryotes), preventing attachment of aminoacyl-tRNA |
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Term
|
Definition
| Bind 30S subunit (a ribosomal subunit in prokaryotes) and inhibit formation of the initiation complex and cause misreading of mRNA |
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Term
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Definition
| Inhibit 50S (a ribosomal subunit in prokaryotes) peptidyltransferase to block peptide bond formation |
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Term
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Definition
| Inhibits Na+K+ATPase sodium pump by binding K+ site |
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Term
| MOA of Cardiac glycosides (digoxin and digitoxin) |
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Definition
Directly inhibit the Na+K+ATPase pump, leading to indirect inhibition of Na+/Ca2+ exchange.
This increases intracellular Ca2+ concentration which increases cardiac contractility. |
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Term
| Treat Cystic fibrosis with ___ |
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Definition
| N-acetylcysteine, to loosen mucous plugs (cleaves disulfide bonds in mucous glycoproteins) |
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Term
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Definition
| inhibits acetaldehyde dehydrogenase (which causes hangover symptoms) |
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Term
| MOA and purpose of Fomepizole |
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Definition
| inhibits alcohol dehydrogenase and is an antidote for methanol or ethylene glycol poisoning |
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Term
| Vitamin E deficiency can cause ___ and ___ |
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Definition
hemolytic anemia (fragil erythrocytes, not protected from free-radical damage)
muscle weakness |
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Term
| MOA and symptoms of arsenic poisoning |
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Definition
inhibits lipoic acid, which is a cofactor for pyruvate dehydrogenase complex (so you can't make acetyl CoA)
vomiting, rice water stools, garlic breath |
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Term
| Treat Cystinuria with ___, and it's MOA |
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Definition
| Acetazolamide, it alkalizes the urine |
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