Term
| Why does the TSH go down in hyperthyroidism |
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Definition
| FEEDBACK TO THE BRAIN TEELLING IT TO SHUT DOWN B/C THERE IS TO MUCH TH |
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Term
| Which laxative contains a synthetic sugar that is hyperosmotic |
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Definition
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Term
| Whic Gout med works by blocking formation of Uric acid |
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Definition
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Term
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Definition
Binds to tubulin causing depolymerization which disrupts cellular fxn decreasing migration into affected area. Blocks cell division by binding to mitotic spindles.
Inhibits Leukocyte entry into affected joint |
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Term
| What is Colchicine used for |
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Definition
| Gout. Not used in acute attacks. Pain reliever |
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Term
| Why is Colchicine not used in acute attacks |
|
Definition
| narrow therapeutic index; GI toxicity |
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Term
|
Definition
| Inhibit reabsorption or uric acid in the proximal renal tubules. Used for GOUT |
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Term
| Which cells dissolve bone in the remodeling process |
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Definition
|
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Term
|
Definition
| Stimulates osteoblasts over osteoclasts. "Human PTH" which leads to greater bone resorption |
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Term
|
Definition
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Term
| Describe the difference btw Pletal & Plavix |
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Definition
Pletal is aplatelet aggregator inhibitor-Inhibits PDEIII which increase cAMP causing vasodilation & inhibiting aggeregation.
Plavix irreversibly modifies the platelt ADP Rc resulting in platelets that are affected for the remainder of their lifespan |
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Term
| What is the difference btw Cytomel & Synthroid |
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Definition
| Cytomel is active & Synthroid is precurser |
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Term
| How do anticholinergics work in treating COPD |
|
Definition
| Prevent increases in intracellular cGMP which are caused by interaction of ACh w/ muscarinic Rc on bronchial smooth mm |
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Term
| Why do B-2-a work in COPD & asthma |
|
Definition
| Potent bronchodilators that relax airway smooth muscle |
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Term
| What is a combo product w/ b-2-a & anticholinergic? |
|
Definition
Combivent
(do not use w/ peanut allergy) |
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Term
| What is a combo product w/ a corcticosteroid & b-2-a |
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Definition
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Term
| Name the famous leukotriene Rc antagonist |
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Definition
|
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Term
|
Definition
| LT Rc antagonist which blocks leukotrienes from causing inflammation |
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Term
| Why is theophylline not used more commonly? |
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Definition
| Narrow therapeutic window can cause cardiotoxicity and arrythmias |
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Term
| What is the therapeutic index of theophylline |
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Definition
|
|
Term
| What are the cough stoppers that are most commonly used |
|
Definition
| codeine & dextromethorpan (DM) |
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|
Term
| What are the 2 products for COPD & asthma that punctured capsule devices |
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Definition
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Term
| Why is it taht patients who take albuterol commonly experience rapid heartbeat |
|
Definition
| +chronotrope due to direct sympathetic effects and peripheral vascular dilation w/ reflex tachy |
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Term
| What drug can be given to astmatics to suppress tremors from B-2-a? |
|
Definition
| Lorazapem. NOT b-blockers |
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|
Term
| Which b-2-a is available in a breath activated MDI |
|
Definition
|
|
Term
| What is the MOA of Atrovent |
|
Definition
Prevents increases in intracellular cGMP by blocking interaction of ACh & muscarinic Rc
(Anticholinergic) |
|
|
Term
| What is the advantage of Spiriva over Atrovent |
|
Definition
|
|
Term
| What are the warnings for LAB2A? |
|
Definition
| may increase risk of asthma-related death |
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|
Term
|
Definition
Salmeterol & Formoterol
**add on therapy only |
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Term
|
Definition
| 2nd msngrs are actiavted and increased (andeylyl cyclase & intracellular cAMP); Protein kinase A is activated which inhibits phosphorylation of myosin & intracellular ionic Ca which dilates bronchioles |
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Term
| What "triggers" should you counsel an asthmatic pt againts? |
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Definition
| ASA, NSAIDS, yellow-colored products |
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|
Term
| What corticosteroid is safe on pregnant pts? |
|
Definition
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|
Term
| What leukotrien Rc antagonist has an unlabeled use for chronic urticaria & atopic dermatitis |
|
Definition
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|
Term
| What are alpha agonists used for? |
|
Definition
|
|
Term
| which Gout medication works by increasing uric acid excretion |
|
Definition
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|
Term
| What foods should be avoided when taking Allopurinol |
|
Definition
| lobster, clam, shellfish, wine, liquor, beer, liver |
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Term
|
Definition
| stool softener (do not take w/ mineral oil) |
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|
Term
|
Definition
| anticholinergic effects and effective in motion sickness |
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|
Term
|
Definition
anticholinergic effect for motion sickness, may produce urinary obstruction sxs
anti-SLUDGE |
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