Term
| Adverse Effects of Rifamycin |
|
Definition
Hepatotoxic
P450 Inducer
Hypersensitivity |
|
|
Term
| Adverse effects of Isoniazid |
|
Definition
Hepatotoxicity
Neurotoxic: Inhibits B6 uptake
Lupus-like
Phenytoin Interaction |
|
|
Term
| Adverse Effects of Ethambutol |
|
Definition
Optic Neuritis: Red-green, and acuity loss
GI symptoms |
|
|
Term
| Adverse Effects of Pyrazinamide |
|
Definition
Most Hepatotoxic of TB Drugs
Hyperureacemia
Arthralgia |
|
|
Term
| Adverse Effects of Streptomycin |
|
Definition
| Nephrotoxicity, Non-reversible Ototoxicity |
|
|
Term
| Adverse effects of Cycloserine |
|
Definition
| Psychosis, Peripheral Neuropathy |
|
|
Term
|
Definition
| Block B1 unit of RNA Polymerase |
|
|
Term
|
Definition
| Block FASII for mycolic acid synthesis |
|
|
Term
|
Definition
| Blocks Arabinosyl Transferase |
|
|
Term
| Mechanism of Pyrazinamide |
|
Definition
| Block FASI in mycolic acid synthesis |
|
|
Term
| Mechanism of Streptomycin |
|
Definition
| Binds 30S subunit of Ribosome |
|
|
Term
|
Definition
| Block D-ala-D-ala Synthetase and Ala Racemase |
|
|
Term
| Is Rifabutin used to treat Rifamycin-resistant TB? Why? |
|
Definition
| resistance is conferred to both |
|
|
Term
| What populations are fast/slow acetylators of INH? |
|
Definition
Fast: Japanese, Inuits
Slow: Scandenavians, Jews |
|
|
Term
| What toxicity screening test are run for the normal course of TB Treatment |
|
Definition
| Liver Function, Renal Function, Vision, Oto, Neuropathy |
|
|
Term
|
Definition
Most Biliary
30% by Renal |
|
|
Term
| Is Rifamycin or Rifabutin a high P450 inducer |
|
Definition
|
|
Term
| Why is Rifamycin never used alone |
|
Definition
| Common Spontaneous Resistance |
|
|
Term
| Which TB Drugs are prodrugs |
|
Definition
|
|
Term
| Aminogycosides besides Streptomycin used in TB Treatment |
|
Definition
|
|
Term
| Flouroquinolones used in Tb |
|
Definition
| Moxifloxacin (MACand TB), Gatifloxacin |
|
|
Term
|
Definition
INH+RIF+PZA+ETH->Sensitive->
INH+RIF+PZA(2 months)-> INH+RIF (4 months, 7 months(HIV))
|
|
|
Term
| Why is ethambutol contraindicated in children under six |
|
Definition
| Optic nerve damage is more prevailent in developing children |
|
|
Term
| What drug is current a second line TB drug but may become a first line because of it effectiveness |
|
Definition
| Fluoroquinolones esp Moxifloxacin |
|
|
Term
What TB drug has...
Optic Neuritis
Neuropathy
Lupus-like
Most Hepatotoxic
Psychosis
Ototoxic
Nephrotoxic
Stephen's Johnson's
Hyperureacemia
Arthralgia
P450 Inducer |
|
Definition
Optic Neuritis: Ethambutol
Neuropathy: Cycloserine, Isoniazid
Lupus-like: Isoniazide
Most Hepatotoxic: Pyrazinamide
Psychosis: Cycloserine
Ototoxic: Streptomycin
Nephrotoxic: Streptomycin
Stephen's Johnson's: Rifamycin
Hyperureacemia: pyraznamide
Arthralgia: pyrazinamide
P450 Inducer: Rifamycin |
|
|
Term
| What is the mechanis of isoniazid neurotoxicity? |
|
Definition
|
|
Term
Which of the quadruple therapy drugs can killed intracellular Mycobacterium?
Which requires a low pH to activate? |
|
Definition
Isoniazid and Pyrazinamide
Low pH: pyrazinamide |
|
|
Term
| How does resistance to Isoniazid occur? |
|
Definition
FASII mutation
Catalase-Peroxidase Mutation |
|
|
