Term
| Which drug has weight based dosing, is very lipophilic and has a large VD? |
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Definition
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Term
| What drug should be given with another anti-epileptic because a rapid decrease in brain concentration can cause rapid seizure recurrence? |
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Definition
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Term
| How frequently can Diazepam be repeated if no response? |
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Definition
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Term
| How frequently can Diazepam be repeated if no response? |
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Definition
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Term
| What drug has minimal reidstribution to fat which results in longer DoA in the CNS? |
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Definition
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Term
| What is the max infusion rate of Lorazepam? |
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Definition
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Term
| what is the max dose of Lorazepam to be given? |
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Definition
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Term
| What is the BZD of choice in SE? |
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Definition
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Term
| Which drug may require a higher dose due to tolerance? |
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Definition
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Term
| Lorazepam offers seizure protection for____ |
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Definition
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Term
| Which drug must be given by continuous infusion? why? |
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Definition
| Midazolam; short half life |
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Term
| Midazolam may be given by ______ if IV access not available. |
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Definition
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Term
| which drug is first line for refractory SE? |
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Definition
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Term
| Hypotension and respiratory depression are effects of____ |
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Definition
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Term
| Patients respond to midazolam in______ |
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Definition
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Term
| with which drug to PTs return to consciousness more rapidly? |
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Definition
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Term
| Which drug is used if no response to BZDs? |
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Definition
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Term
| Hypotension or cardiac arrhythmias may arise due to _______as the drug vehicle fo _______ |
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Definition
| propylene glycol is the drug vehicle for phenytoin |
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Term
| Which drug has an alkaline pH, can cause burning during infusion, and may cause phlebitis and necrosis? |
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Definition
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Term
| Phenytoin is not first line because_____ |
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Definition
| infusion rate is limited and cannot be delivered fast enough |
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Term
| max infusion rates for phenytoin? |
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Definition
50 mg/min in adults
.5-1 mg/kg/min in children |
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Term
| ____is a phenytoin prodrug |
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Definition
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Term
| Fosphenytoin is easier to administer because_____ and therefore does not cause_____. |
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Definition
| it is water soluble and has no propylene glycol; BP or EKG changes |
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Term
| Drug's AE's are: Nystagmus, ataxia, BP changes (less than phenytoin), nonallergic parathesias and facial & groin itching |
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Definition
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Term
| Which drug has SEs of apnea and hypoapnea? |
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Definition
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Term
| This drug also has propylene glycol, but may be delivered faster than phenytoin |
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Definition
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Term
| how frequently may phenobarb be given? |
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Definition
| 20-30 minutes after 1st dose; a 3rd may be given (10mg/kg) |
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Term
| What is given if a PT does not respond to Midazolam? |
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Definition
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Term
|
Definition
| LD followed by continuous infusion |
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Term
| Which drug may cause hypotension? |
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Definition
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Term
| This drug should be given with other antiepileptics at therapeutic doses to decrease risk of seizure recurrence upon withdrawal |
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Definition
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Term
| Which drug has comparative efficacy to midazolam and has SEs of metabolic acidosis and arrhythmias? |
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Definition
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Term
| Which drug has a very short t 1/2 to promote rapid awakening on withdrawal? |
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Definition
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Term
| Which drug is extremely rapid onset, extremely lipid soluble, and can provide over 1000 calories/day in lipid form? |
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Definition
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Term
| Which drug must have its acid-base status monitored and maintain hydration to prevent kidney stones? |
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Definition
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Term
| Which drug is not recommended because accumulation can cause CNS toxicity? |
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Definition
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