Term
| Can direct acting agents be abruptly discontinued? |
|
Definition
| No, it may cause withdrawal or rebound effects. |
|
|
Term
| What are side effects of an Alpha-1 blockade? |
|
Definition
| Orthostatic hypotension, reflex tachycardia, dizziness, syncope, impotency |
|
|
Term
| What are side effects of histamine blockade? |
|
Definition
| Sedation, lethargy, weight gain |
|
|
Term
| What neurotransmitter is related to emotions and the reward center? |
|
Definition
|
|
Term
| Is GABA an excitatory or inhibitory neurotransmitter? |
|
Definition
|
|
Term
| Is Acetycholine an excitatory or inhibitory neurotransmitter? |
|
Definition
|
|
Term
| Is Norepinephrine excitatory or inhibitory? |
|
Definition
|
|
Term
| Is Dopamine excitatory or inhibitory? |
|
Definition
|
|
Term
| Is Glutamate excitatory or inhibitory? |
|
Definition
|
|
Term
| Is Substance P excitatory or inhibitory? |
|
Definition
|
|
Term
| What neurotransmitters increas Cl- flux in postsynaptic neurons |
|
Definition
|
|
Term
| Is Glycine excitatory or inhibitory? |
|
Definition
|
|
Term
| What stage of sleep is associated with bed wetting, sleep walking and talking, and night terrors? |
|
Definition
|
|
Term
| How long does it take to enter REM sleep? |
|
Definition
| After 90 minutes of sleep |
|
|
Term
| Do young or elderly have lighter and more fragmented sleep? |
|
Definition
|
|
Term
| How long do complaints of difficulty falling and/or maintaining sleep or a non-restorative sleep need to last before a diagnosis of insomnia? |
|
Definition
|
|
Term
| Do young adults have difficulty falling or staying asleep? |
|
Definition
|
|
Term
| Are sedating antihistamines used for short or long term treatment of insomnia? |
|
Definition
|
|
Term
| What is the mechanism of action for sedating antihistamines? |
|
Definition
| Central blockade of histamine-1 and cholinergic receptors. Also blocks peripheral histamine-1, alpha, and cholinergic receptors |
|
|
Term
| Do sedating antihistamines restore or promote sleep? |
|
Definition
|
|
Term
| Is there drug hangover with sedating antihistamines? |
|
Definition
|
|
Term
| What is an alternative drug option for patients needing restorative sleep but cannot be treated with a benzodiazepine? |
|
Definition
|
|
Term
| What is the name of the medication give to patient with a history of substance abuse for maintenance of sleep? |
|
Definition
|
|
Term
| What is the name of the alternative medication for sleep disorders? |
|
Definition
|
|
Term
| What drug is indicated to promote the onset of sleep? |
|
Definition
|
|
Term
| Does Ramelteon cause drug hangovers? |
|
Definition
| Yes, since it has a half-life of up to 5 hours |
|
|
Term
| What is a serious adverse reaction associated with Ramelteon and other sleep medications? |
|
Definition
|
|
Term
| Can you drink alcohol while taking Ramelteon? |
|
Definition
|
|
Term
| What are the 3 drugs that shouldn't be taken with Ramelteon? |
|
Definition
| Fluvoxamine, Protease inhibitors, and anticonvulsants |
|
|
Term
| Which zolpidem is used for sleep induction? |
|
Definition
|
|
Term
| Which zolpidem is used for sleep maintenance? |
|
Definition
|
|
Term
| How does zolpidem, zaleplon, and eszcopiclone work? |
|
Definition
| Bind to benzodiazepine receptors, resulting in enhanced GABA-associated hyperpolarization |
|
|
Term
| Are zolpidem, zaleplon, and eszopiclone safe to use in patients with sleep apnea or COPD? |
|
Definition
|
|
Term
| Is there drug hangover with zolpidem, zaleplon, and eszopiclone? |
|
Definition
|
|
Term
| What is the name of the antagonist to Zolpidem, Zaleplon, and Eszopiclone? |
|
Definition
|
|
