Term
| Amphetamine (release DA) Cocaine (prevents re-uptake of DA) INTOXICATION |
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Definition
| physio arousal outside cortical control fatigue, tachy, pup dilation, euphoria |
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Term
| Amphetamine (release DA) Cocaine (prevents re-uptake of DA) WITHDRAWAL |
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Definition
| increased appetite, unpleasant dreams, depression fatigue |
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Term
| Amphetamine (release DA) Cocaine (prevents re-uptake of DA) TREATMENT |
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Definition
| Antipsychotics, benzodiazepines, bromocriptine, amantadine, desipramine |
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Term
| Caffeine(adenosine receptor antagonist - ^cAMP) INTOXICATION |
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Definition
| Restlessness, agitation, insomnia, diuresis, GI disturbances, excitement |
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Term
| Caffeine (adenosine receptor antagonist - ^cAMP) WITHDRAWAL-Tx |
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Definition
| -Headache, fatigue, drowsiness, N/V. -Avoid caffeine, analgesics |
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Term
| Marijuana (inhib G protein, ^GABA, ^serotonin, lower level of NAC activation) INTOXICATION |
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Definition
| Impaired motor, anxiety, slowed reaction time, conjunctival injection, dry mouth, increased appetite |
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Term
| Hallucinogens ("partial" agonists at postsynaptic 5-HT receptors) INTOXICATION |
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Definition
| ", illusions, anxiety, ideas of reference, depersonalization, pup dilation, tremors, uncoordination |
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Term
| Hallucinogens ("partial" agonists at postsynaptic 5-HT receptors) Tx - Versions |
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Definition
| -Supportive counseling, talking down, anti-psychotics or benzodiazepines -ASD=<30 days, PTSD=>30 days |
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Term
| Inhalants (GABA, cross tolerance, cerebellum) INTOXICATION |
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Definition
| Belligerence, nystagmus, lethargy, unsteady gait, crusting/small cuts/sores around nose/mouth |
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Term
| Inhalants (GABA, cross tolerance, cerebellum) Tx - MC |
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Definition
| -Education, counseling -poor, young, not drug sophisticated |
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Term
| Nicotine (Ach receptor agonist, activates dopaminergic pathway - speeds/potentiates glutamate flow) WITHDRAWAL |
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Definition
| Irritability, depressed mood/HR, prolonged ^appetite, insomnia, anxiety |
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Term
| Nicotine (Ach receptor agonist, activates dopaminergic pathway - speeds/potentiates glutamate flow) Tx |
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Definition
| Bromocriptine (prophylactic, #1 tx), buproprion |
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Term
| Opiates: Heroin, Codeine, Oxycodone (opiate receptors, locus cereleus pathway/noradrenergic), NAC pathway INTOXICATION |
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Definition
| Pup constriction, constipation, drowsiness, slurred speech, resp depression, brady, coma |
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Term
| Opiates: Heroin, Codeine, Oxycodone (opiate receptors, locus cereleus pathway/noradrenergic), NAC pathway WITHDRAWAL |
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Definition
| "Worst flu ever," yawning, piloerection, lacrimation, rhinorrhea, fever, insomnia, pup dilation |
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Term
| Opiates: Heroin, Codeine, Oxycodone (opiate receptors, locus cereleus pathway/noradrenergic), NAC pathway Tx |
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Definition
| Naloxone (injected:short 1/2 life) Naltrexone (longer 1/2 life) Clonidine (ease withdrawal) Methadone (more addictive than heroin) LAMM, buprenorphine (detox) |
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Term
| Phencyclidine:PCP, angel dust (N-methyl-D-aspartate glutamate receptors, prevents Ca ion influx, activates dopaminergic neurons) INTOXICATION |
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Definition
| Assaultive, agitated, nystagmus, ataxia, hypersalivation, muscle rigidity, decreased response to pain, hyperacusis |
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Term
| Phencyclidine:PCP, angel dust (N-methyl-D-aspartate glutamate receptors, prevents Ca ion influx, activates dopaminergic neurons) Tx |
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Definition
| Nonstimulating environment, restraints, Vit C, benzodiazepines, antipsychotics, |
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Term
| Sedative hypnotics: barbituates, benzodiazepines (GABA, cross-tolerance, delirium) INTOXICATION |
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Definition
| Impaired judgment, slurred speech, uncoordination, unsteady gait, stupor, coma |
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Term
| Sedative hypnotics: barbituates, benzodiazepines (GABA, cross-tolerance, delirium) WITHDRAWAL |
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Definition
| Autonomic hyperactivity tremors, hyperactivity; hallucinations, anxiety, grand mal seizures |
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Term
| Sedative hypnotics: barbituates, benzodiazepines (GABA, cross-tolerance, delirium) Tx |
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Definition
| Barbituates: Pentobarbital challenge test Benzodiazepines (slowly taper dose) |
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Term
| Ecstasy:MDMA/amphetamine & hallucinogen (serotonin receptor destruction) INTOXICATION |
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Definition
| ^Impulsiveness, dehydration |
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Term
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Definition
| Cardiomyopathy, bone mineral loss w/ later osteoporosis, HTN, DM, mood depression, atypical psychosis, skin atrophy, spont. bruising, acne, low serum K+ levels |
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