Term
| decrease binding forces within the horny layer, enhances desquamation and eliminates scaling |
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Definition
| Emollients (ex: Lubriderm) |
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Term
| disrupt coenocyte to coenocyte cohesion in the abnormal horny layer |
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Definition
| Keratolytic (salicylic acid) |
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Term
| salts reduce activated T cells in skin |
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Definition
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Term
| modulates keratinocyte proliferation and differentiation |
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Definition
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Term
| not completely understood, inhibits phospholipase A and reduction arachadonic acid, prostaglandins, leukotrienes |
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Definition
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Term
| not well understood, down regulation of epidermal proliferation leading to reduction in plaque elevation, stimulate transient epidermal hyperplasia, follow by cytostatic effect with epidermal thinning |
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Definition
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Term
| antiproliferative activity on human keratinocytes inhibiting DNA synthesis and inhibition of transcription inflammatory cytokines |
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Definition
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Term
| inhibits keratinocyte differentiation and proliferation and provides anti-inflammatory benefit by shifting to an increase in T helper cells type 2 cytokine decrease IL 1,6,8 and decrease interferon gamma |
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Definition
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Term
| unclear, proposed effects include: inhibition of neutrophil migration, reduction in epidermal concentration of polyamines |
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Definition
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Term
| inhibits 1st phase of T cell activation |
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Definition
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Term
| Inhibits t cell activation and only used for severe psoriasis |
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Definition
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Term
| acts as a competitive inhibitor of dihydrolate reductase subsequently inhibiting DNA and RNA synthesis because tetrahydrofolate is responsible in helping with synthesis of nucelotides, which inhibits replication and function of B and T cells which inhibit epidermal cell division |
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Definition
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Term
| anti-inflammatory activity by inhibiting 5-lipoxygenase |
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Definition
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Term
| inactivates ribonucleotide reductase; inhibiting cell wall synthesis in S phase |
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Definition
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Term
| immunomodulator, anti-proliferative, anti-inflammatory, immunosuppressie effects |
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Definition
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Term
| chimeric monoclonal antibody directed against TNF alpha |
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Definition
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Term
| blocks TNF alpha, fusion protein and fully humanized (less risk of antibody development) |
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Definition
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Term
| human IgG1 monoclonal TNF alpha antibody, inactivates TNF alpha by binding to it |
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Definition
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Term
| dimeric fusion protein nad inhibits T-cell activation and proliferation (inactivation of T cells) |
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Definition
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