Term
|
Definition
| conglomerates prepared from powders |
|
|
Term
| production methods for powders |
|
Definition
molecualar aggregation
&
communition |
|
|
Term
| molecular aggregation powder production method |
|
Definition
crystallization
&
precipitation
(superstaturated solution) |
|
|
Term
| communition powder production methods |
|
Definition
trituration
levitation
pulverization
Grind |
|
|
Term
|
Definition
| reduce particle size with mortar and pestle |
|
|
Term
|
Definition
| add levigating agent and form paste using mortar and pestle |
|
|
Term
|
Definition
| powder is dissolved in non volatile solvent(alcohol) and solution is evaporated leaving a fine powder |
|
|
Term
|
Definition
spatulation
trituration
geometric dilution
tumbling
sifting |
|
|
Term
|
Definition
using a spatula
-for small amounts
-solids that liquify
-solids that form eutectic mixtures
(melting point is lowered when mixed together) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| small amount of drug with large amount of excipient = dilutents + drug inequal volumes until completely mixed |
|
|
Term
|
Definition
| large scale mixing, time consuming |
|
|
Term
|
Definition
| for light and fluffy powders, not suitable for dilution of potent drug |
|
|
Term
| types of powder preparations |
|
Definition
bulk powders
pre packaged powders
powder in a bottle |
|
|
Term
|
Definition
- patients measure individual dose
- can lead to dosing inaccuracy. Ex: metamucil |
|
|
Term
|
Definition
| individual doses & powder papers used |
|
|
Term
|
Definition
| thin, semi opaque powder paper |
|
|
Term
|
Definition
|
|
Term
|
Definition
| glazed and transparent powder paper |
|
|
Term
|
Definition
| transparent waterproof powder paper |
|
|
Term
|
Definition
- usually for clinical trials
- allows dose manipulation |
|
|
Term
| effervescent salt - definition |
|
Definition
- granules or powders consisting of sodium bicarb and organic or inorganic acid
(citric acid/tartaric acid)
-granules are coarse to very course |
|
|
Term
| effervescent salts - function |
|
Definition
- release carbon dioxide
- masks taste
- transiently lowers pH, which can
help with absorption |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
bulk powders
dentrifices
douche powders |
|
|
Term
| compound clioquinol powder |
|
Definition
|
|
Term
| methybenzethonium chloride powder |
|
Definition
|
|
Term
| neomycin, polymycin b sulfates, bacitracin zinc powders |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| microcrystalline cellulose |
|
Definition
|
|
Term
|
Definition
tablets
capsules
ointments
pastes
suppositiories
liquid dosage forms |
|
|
Term
| conventional dosage forms |
|
Definition
immediate release
and
various administration routes |
|
|
Term
| modified/controlled/sustained/prolonged dosage form |
|
Definition
- drug release is controlled by the system
- drug release from a drug delivery system is modified
- time course or location of drug delivery can be changed |
|
|
Term
|
Definition
solid
liquid
semi solid
special |
|
|
Term
| powder dosage form advantages |
|
Definition
- flexible dosing
- good chemical stability
- fast dissolution rate
- easy to swallow if mixed w/food/drink |
|
|
Term
| powder form disadvantages |
|
Definition
- inaccuracy of dose, hard to measure
- unsuitable for bad tasting
- unsuitable for hygroscopic
(drugs that absorb water from environment)
- unsuitable for deliquescent
(broken down by stomach) |
|
|
Term
| particle size of powders affect |
|
Definition
- dissolution rate
- suspendability
- uniformity
- penetrability for topical
(absorbed through skin)
- grittiness |
|
|
Term
|
Definition
measures how free flowing a powder is
- the smaller the angle, the more free flowing
- take the slope of a powder cone
|
|
|
Term
|
Definition
1. pharmaceutical preparation (underline)
2. mixture (check mark)
3. dry particles (check mark) |
|
|
