Term
| Alpha Adrenergic Toxidrome |
|
Definition
Hypertension with reflex bradycardia
CNS excitation
sweating, dilated pupils, decreased bowel sounds
Phenylephrine |
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Term
| Anticholinergic toxidrome |
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Definition
mad as a hatter, dry as a bone, blind as a bat, red as a beet, hot as a hare
tachycardia, hypertension
antihistamines, TCA, atropine, scopolamine
If antidote needed, use benzos, and sometimes physostigmine |
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Term
| beta adrenergic toxidrome |
|
Definition
tachicardia
seizures
constricted pupils
hyperglycemia, hypokalema
tremor
albuterol, caffeine |
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Term
|
Definition
SLUDGE
die from bronchorrhea, muscle fasciculations, and paralyssi
OPs, insecticides |
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|
Term
| mixed adrenergic/sympathomimetic toxidrome |
|
Definition
a lot like anticholinergic, but moist skin
amphetamine, cocaine |
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Term
|
Definition
hpertension, tachycardia then bradycardia
moist skin
hyperactive bowel
muscle fasciculations, then paralysis |
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|
Term
|
Definition
hypothermia, hypopnea, apnea
lethargy, coma
pinpoint pupils
decreased bowel sounds
codeine, morphine, etc |
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|
Term
| sedative-hypnotic toxirome |
|
Definition
poikilothermy, hypopnea, hypotension
coma
dilated pupils
barbiturates, ethanol, benzos |
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|
Term
|
Definition
hyperthermia, tachycardia, diarrhea
hypertonia, clonus
confusion, agitation
Usually a drug-drug interaction
SSRI, TCA, MAOI, etc
Rx: stop culprits. If must, use benzos |
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|
Term
|
Definition
hypothermia, hypotension, apnea
lethargy, coma
constricted pupils
clonidine, oxymetazoline, etc |
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|
Term
| Causes of anion gap metabolic acidosis |
|
Definition
MUDPILES
Methanol
Uremia
DKA
Inhaled, iron, INH
Lactic acidosis
Ethylene glycol
Salicylates, stimulants/sympathomimetics |
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|
Term
| Antidote for acetaminophen |
|
Definition
|
|
Term
|
Definition
| antidote for acetaminophen |
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|
Term
|
Definition
|
|
Term
|
Definition
antidote for benzos
be careful, this can cause seizures! |
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|
Term
|
Definition
antihistamine
anticholinergic toxidrome
antidote- sodium bicarbonate |
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|
Term
|
Definition
cause hypoglycemia
great with glucose, octreotide, D5, D10 |
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|
Term
|
Definition
blocks insulin release
treats hypoglycemia |
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|
Term
|
Definition
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|
Term
| antidote of carbon monoxide |
|
Definition
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|
Term
|
Definition
blocks cytochome c oxidase
antidotes:
- hydroxocobal- makes B12
- sodium nitrite- makes MetHb, dangerous
- sodium thiosulfate- ehnhances endogenous rhodanese |
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|
Term
|
Definition
- antidote for cyanide
- makes B12
- safe but expensive |
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|
Term
|
Definition
- antidote for cyanide
- Hb->MetHb
- causes vasodilation, so dangerous |
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|
Term
|
Definition
- antidote for cyanide
- enhances endogenous rhodanese
- inexpensive and safe |
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|
Term
| Antidote for toxic alcohols |
|
Definition
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|
Term
| Effects of ethylene glycol |
|
Definition
| renal failure, seizure, stroke, death |
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|
Term
|
Definition
| blindness, acidosis, seizure, death |
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Term
|
Definition
| antidote for toxic alcohols |
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|
Term
| antidotes for organophosphates |
|
Definition
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