Term
| 2ndary HA warning sign #? |
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Definition
|
|
Term
| 2ndary HA warning sign onset? |
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Definition
|
|
Term
| 2ndary HA warning sign age? |
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Definition
|
|
Term
| 2ndary HA warning sign systemic? |
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Definition
| fever, myalgia, weight loss |
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Term
| 2ndary HA warning sign concommitant disease? |
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Definition
|
|
Term
| 2ndary HA warning sign pattern? |
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Definition
| progressive, freq/severity |
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|
Term
| 2ndary HA warning sign PE? |
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Definition
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Term
| classes of meds specific for migraines? |
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Definition
|
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Term
| 2+ of the following for dx migraine |
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Definition
| pulsating, unilateral, mod/severe pain, aggravated by routine activity |
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Term
| 1+ of the following for dx migraine |
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Definition
|
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Term
| some manifestations of aura |
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Definition
| soctoma, scintillations, hemipar, numb, dysasthesia |
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Term
|
Definition
| dull, nonpulsatile pain, pressure, not aggravated by activity, only one of N/photo/phonophobia |
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Term
| can a pt have photo/phonophobia and not have a migraine? |
|
Definition
| yes, if only one is present |
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|
Term
| classic age/sex for cluster HAs? |
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Definition
|
|
Term
| associated neuro sx with cluster HAs? |
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Definition
|
|
Term
| NT implicated in migraine? |
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Definition
|
|
Term
| 5HTR for migraine therapy? |
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Definition
|
|
Term
| how might reserpine trigger a migraine? |
|
Definition
|
|
Term
| why might sleep trigger a migraine? |
|
Definition
| dorsal raphe cells quit releaseing 5HT |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
|
Term
| triptan response at 2 hours? |
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Definition
|
|
Term
| MOA triptan (not just receptor specificity) |
|
Definition
| cranial vasoconstriction, neuronal inhibition |
|
|
Term
| what cranial nerve has been implicated in migraine? |
|
Definition
|
|
Term
|
Definition
| dizzy, somnelent, fatigue, parasthesia, chest sx |
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|
Term
| contraindications for triptans |
|
Definition
| CARDIAC OR PER VASC DISEASE OR HTN, hepatic impairment, SSRI, breastfeeding |
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|
Term
| proposed MOA of ergot alkaloids |
|
Definition
| inhibit neurogenic inflammation |
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|
Term
| receptors for ergot alkaloids |
|
Definition
|
|
Term
| big SE of ergot alkaloids |
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Definition
|
|
Term
| contraindications for EA? |
|
Definition
|
|
Term
| what sort of migraine should not be treated with triptans or EAs? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| gen classes for migraine prevention |
|
Definition
| anticonv, AD, BB, CCB, NSAIDs, ser antagonists |
|
|
Term
| discuss the "complex role of serotonin in migraine" as it is proven by migraine rx... |
|
Definition
| antagonists for prevention, agonists for treatment |
|
|
Term
| biggie rx for cluster HA? |
|
Definition
|
|
Term
| prevention of cluster HA? |
|
Definition
|
|
Term
|
Definition
| nephro DI, thyroid, tremor |
|
|
Term
|
Definition
| heart disease, brady, DMI |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| prevention of tension HA? |
|
Definition
| TCA, anticonv, muscle relax |
|
|
Term
| what is the most commonly removed seizure focus? |
|
Definition
| part of non-dom temporal lobe |
|
|
Term
|
Definition
| phenobarb, phenytoin, ethosuxamide, carbemazepine, divalproex Na |
|
|
Term
| anticonvulsive inhibitors of CYP450 |
|
Definition
|
|
Term
| anticonvulsive inducers of CYP450 |
|
Definition
| all the oldies except valproate |
|
|
Term
| thing to remember with carbemazepine? |
|
Definition
| it autoinduces its own metabolism |
|
|
Term
| what's the deal with felbamate? |
|
Definition
| it is an newer ACNV with serious side effects, a "last-ditch" option |
|
|
Term
|
Definition
|
|
Term
| drug of choice for all types of seizure? |
|
Definition
|
|
Term
| drug of choice for partial w/ or w/o 2ndary GTC? |
|
Definition
|
|
Term
| drug of choice for primary GTC? |
|
Definition
|
|
Term
| drug of choice for abscence? |
|
Definition
|
|
Term
| drug of choice for atypical absence, myoclonic, or atonic seizure? |
|
Definition
|
|
Term
| why must you monitor ACNVs closely? |
|
Definition
| narrow therapeutic window |
|
|
Term
| which ACNVs have high plasma protein binding? |
|
Definition
|
|
Term
|
Definition
| Na blocker, inhibition repetitive APs |
|
|
Term
|
Definition
|
|
Term
| why is there not a linear dose/plasma conc relationship with phenytoin? |
|
Definition
|
|
Term
| big interaction with phenytoin |
|
Definition
|
|
Term
|
Definition
| EtOH like, gingival hyperplasia, hirsuitism, terato, RASH |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| clinical use of carbemazepine |
|
Definition
| partial seizure, 2dary GTC, V neuralgia, mania/mood |
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|
Term
|
Definition
| neuro stuff (diplopia, ataxia), GI, rash, BONE MARROW SUPPRESSION, nausea, sedation, hypoNa |
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|
Term
|
Definition
|
|
Term
| clinical use of phenobarbital |
|
Definition
|
|
Term
|
Definition
| sed/drow, cog impair, TERATOGEN |
|
|
Term
|
Definition
| metabolized into 3 ACNV including pheno |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| gastric, HA, N+V, eosinophilia, leukopenia, SLE (rare) |
|
|
Term
|
Definition
| dec Na conductance, inhibit GABA catabolism |
|
|
Term
|
Definition
| all seizures, bipolar, migraine prophylaxis |
|
|
Term
| clinical use of clonazepam? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what is the most common add-on AED and why? |
|
Definition
| levetiracetam, no protein binding, no hepatic metabolism |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| duration of abscence seizure? |
|
Definition
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