Term
| what must be present to call a pt "substance dependant?" |
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Definition
| tolerance, withdrawl, unsuccesful efforts to cut down etc |
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|
Term
| is dependence the same as addiction? |
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Definition
|
|
Term
| receptors at which EtOH works |
|
Definition
| gaba, glu, mu, cannab, ach, ser, ca |
|
|
Term
|
Definition
| EtOH-->acetaldehyde-->acetic acid |
|
|
Term
| two big sx of EtOH withdrawl |
|
Definition
|
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Term
|
Definition
|
|
Term
| what is Wernicke's triad? |
|
Definition
| confusion, ataxia, ophthalmoplegia |
|
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Term
|
Definition
| inhibit aldehyde dehydrogenase |
|
|
Term
| what drug can help with alcohol abuse in terms of "dry days" and "time to first drink?" |
|
Definition
|
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Term
|
Definition
| NMDA med interference w/ glu? |
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Term
|
Definition
|
|
Term
| why is cannabis a "safe" drug? |
|
Definition
| minimal THCR in the brainstem |
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Term
|
Definition
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Term
|
Definition
|
|
Term
| CNS vs NMJ effects of nicotine? |
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Definition
|
|
Term
| what produces the reinforcement effect of nicotine? |
|
Definition
|
|
Term
| how does Bupropion help in nicotine cessation? |
|
Definition
|
|
Term
| why does amphetamine have a greater amount of accumulation of synaptic NT than cocaine? |
|
Definition
|
|
Term
| what mediates amphetamines releasing potential? |
|
Definition
|
|
Term
| what mediates reward behavior for the stimulant drugs? |
|
Definition
| mesolimbic DA path (VTA-->NA) |
|
|
Term
|
Definition
| dec fatigue/inc alertness |
|
|
Term
| what happens to cocaine in the plasma? |
|
Definition
| readily metabolized by plasma/liver enzymes |
|
|
Term
| bioactive product of cocaine met? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what happens when you drink and snort? |
|
Definition
| coc-ethylene --> longer hl |
|
|
Term
| why does cocaine tend to accumulate in the fetus? |
|
Definition
| low pH of fetal blood and weak esterases |
|
|
Term
| what does cocaine do to fetal blood flow? |
|
Definition
|
|
Term
|
Definition
| propranolol, diazepam, Ca-channel blockers |
|
|
Term
| acute withdrawl rx for cocaine? |
|
Definition
| bromocriptine (DA ag), diazepam |
|
|
Term
| long term/addiction rx for cocaine? |
|
Definition
|
|
Term
| what happens to amphetamines at nerve terminals? |
|
Definition
|
|
Term
| amphetamines in the urine? |
|
Definition
|
|
Term
| do amphetamines have bioactive metabolites? |
|
Definition
|
|
Term
| what can degenerate with long term amphetamine use? |
|
Definition
| caudate (DAergic terminal) |
|
|
Term
| what does meth do to the brain (structure) |
|
Definition
| degen of caudate and frontal cortex (DA), hippocampus (5HT), cell bodies intact, terminals out |
|
|
Term
|
Definition
| dorsal raphe/cortical 5HT degeneration |
|
|
Term
| what are serotonin like hallucs? |
|
Definition
|
|
Term
| what are catecholamine like hallucs? |
|
Definition
|
|
Term
| how do we know that most of the action of the hallucs are frontal cortical? |
|
Definition
| they are not self-administer to aminals |
|
|
Term
|
Definition
|
|
Term
| duration of effects of LSD? |
|
Definition
|
|
Term
| which receptor seems to be the key in LSD? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| cross tolerance with LSD? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| does PCP cross the placenta? |
|
Definition
|
|
Term
|
Definition
| NMDAR antago, 5HT/DA/NE RI |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| gastric lavage, acid urine, diaz, antipsychotics PRN |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| hep met (gluc)/ren excret |
|
|
Term
| anatomical mech of opiods |
|
Definition
| inc firing rate of VTA DAergics and LC NAergics |
|
|
Term
| effects of opiods that develope tolerane |
|
Definition
|
|
Term
| no tolerance to these effects of opiods |
|
Definition
| miosis, constipation, convulsions |
|
|
Term
|
Definition
| regular naloxone, or naltrexone |
|
|
Term
| controlled withdrawl from opiods rx |
|
Definition
|
|
Term
| new withdrawl drugs for opiods |
|
Definition
|
|
Term
|
Definition
| long acting opiod agonist |
|
|
Term
|
Definition
| partial mu agonist with long doa |
|
|
Term
|
Definition
| inhibit adenylyl cyclase via Gprot |
|
|
Term
| effect of opiodR on neuronal activity? |
|
Definition
| inhibit via inc K or dec Ca |
|
|
Term
| opiod with greatly enhanced efficacy? |
|
Definition
|
|
Term
| opiod with dec abuse potential |
|
Definition
|
|
Term
| opiod with long doa and inc oral availability |
|
Definition
|
|
Term
| opiods and the first pass effect... |
|
Definition
| most of them are broken down significantly |
|
|
Term
| opiods with good oral bioavailability |
|
Definition
| methadone, oxycodone, leverphanol |
|
|
Term
| how does morphine produce respiritory depression? |
|
Definition
| dimished response of medulla to inc in pCO2 |
|
|
Term
| effects of morphine at the EWN |
|
Definition
|
|
Term
| effect of morphine on GI tract/urinary sys |
|
Definition
|
|
Term
| triad of narcotic overdose? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| why is meperidine good for OB? |
|
Definition
| it doesn't depress neonatal resp as much as equianalgesic doses of morphine |
|
|
Term
|
Definition
| 80x potency, shorter resp depress |
|
|
Term
| how does codeine supress cough? |
|
Definition
|
|
Term
| why is pentazocine less abused than morphine? |
|
Definition
| antag/partial ag MOR as dose is elevated |
|
|
Term
| tolerance/withdrawl with pentazocine? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
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